121103-58-0Relevant articles and documents
Synthetic Studies Relevant to Biosynthetic Research on Vitamin B12. Part 9. Synthesis of 20-Methyl and 20-Cyano Isobacteriochlorins
Arnott, David M.,Harrison, Peter J.,Henderson, Graeme B.,Sheng, Zhi-Chu,Leeper, Finian J.,Battersby, Alan R.
, p. 265 - 278 (2007/10/02)
Isobacteriochlorins carrying a C-methyl group at C-20 of the macrocycle are important for research on the biosynthesis of vitamin B12.Several different approaches are studied which allow the introduction of a C-20 methyl group into model isobacteriochlorins, the most successful involving the stepwise reduction of a nitrile residue to a methyl group.Successful syntheses are described of two 20-methylisobacteriochlorins and two 20-cyanoisobacteriochlorins.All the routes used depend finally on the photochemical cyclisation of an 18?-electron open-chain precursor.