1211283-99-6

Basic information

• Product Name: 2-methyl-N-(3-phenyloxetan-3-yl)propane-2-sulfinamide
• Synonyms: 2-methyl-N-(3-phenyloxetan-3-yl)propane-2-sulfinamide
• CAS NO: 1211283-99-6
• Molecular Weight: 253.365
• Mol File: 1211283-99-6.mol

Chemical Properties

• CAS DataBase Reference: 2-methyl-N-(3-phenyloxetan-3-yl)propane-2-sulfinamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-methyl-N-(3-phenyloxetan-3-yl)propane-2-sulfinamide(1211283-99-6)
• EPA Substance Registry System: 2-methyl-N-(3-phenyloxetan-3-yl)propane-2-sulfinamide(1211283-99-6)

Safety Data

• Hazardous Substances Data: 1211283-99-6(Hazardous Substances Data)

Upstream product

• 108-86-1 bromobenzene 
• 1158098-73-7 (±)-2-methyl-N-(oxetan-3-ylidene)propane-2-sulfinamide 
• 3262-89-3 triphenylboroxine 

Downstream Products

• 1211284-11-5 3-phenyl-3-aminooxetane hydrochloride 
• 1380656-45-0 4-fluoro-2-(4-fluorophenyl)-N-methyl-5-(2-methyl-5-(3-phenyloxetan-3-ylcarbamoyl)phenyl)benzofuran-3-carboxamide 

Relevant articles and documents

BICYCLIC COMPOUNDS

Provided herein are compounds and pharmaceutical compositions comprising said compounds that are useful for treating cancers. Specific cancers include those that are mediated by YAP/TAZ or those that are modulated by the interaction between YAP/TAZ and TEAD.

Discovery of N-Cyano-sulfoximineurea Derivatives as Potent and Orally Bioavailable NLRP3 Inflammasome Inhibitors

NLRP3 inflammasome mediated release of interleukin-1β (IL-1β) has been implicated in various diseases. In this study, rationally designed mimics of sulfonylurea moiety were investigated as NLRP3 inhibitors. Our results culminated into discovery of series of unprecedented N-cyano sulfoximineurea derivatives as potent NLRP3 inflammasome inhibitors. Compound 15 (IC50 = 7 nM) and analogues were found to be highly potent and selective NLRP3 inflammasome inhibitor with good pharmacokinetic profile. These effects translate in vivo, as 15, 29, and 34 significantly inhibit NLRP3 dependent IL-1β secretion in mice.

BENZOFURANE DERIVATIVES FOR THE TREATMENT OF HEPATITITS C

The disclosure provides compounds of formula I, including their salts, as well as compositions and methods of using the compounds. The compounds have activity against hepatitis C virus (HCV) and maybe useful in treating those infected with HCV.

Highly functional group compatible Rh-catalyzed addition of arylboroxines to activated N-tert-butanesulfinyl ketimines

The rhodium-catalyzed addition of readily accessible arylboroxines to N-tert-butanesulfinyl ketimines derived from oxetan-3-one, N-Boc-azetidin-3-one, and isatins proceeds in high yields with excellent functional group compatibility. Moreover, high diastereoselectivities are observed for the additions to the N-sulfinyl ketimines derived from isatins.

Reactions of oxetan-3-tert-butylsulfinimine for the preparation of substituted 3-aminooxetanes

(Figure Presented) The oxetane ring Is useful In drug discovery as a bioisostere for both the geminal dimethyl group and the carbonyl group. A convenient, straightforward approach to access structurally diverse 3-aminooxetanes through the reactivity of oxetan-3-tert-butylsulfinimine and the corresponding sulfinylaziridine Is described.