121133-08-2

Upstream product

• 3731-38-2 3-Quinuclidinone 
• 144632-21-3 3-(Methoxy-phenylsulfanyl-methyl)-1-aza-bicyclo[2.2.2]octan-3-ol 
• 51233-80-8 2,6-dimethylphenyl propionate 
• 121133-07-1 3-Phenylthio-1-azabicyclo<2.2.2>octane-3-carbaldehyde 

Downstream Products

• 121133-11-7 (2RS,3RS,3'SR)-3-Hydroxy-2-methyl-3-(3'-phenylthio-1'-azabicyclo<2.2.2>octan-3'-yl)propyl Benzoate 
• 121133-10-6 (3RS,4SR,3'SR)-4'-Methyl-3'-(phenylthio)(1-azabicyclo<2.2.2>octane)-3-spiro-2-tetrahydrofuran 
• 121133-12-8 (2RS,3SR)-3-(1'-Azabicyclo<2.2.2>oct-2'-en-3'-yl)-2-methyl-3-(phenylthio)propyl Benzoate 
• 121160-46-1 (3RS,4SR,3'SR)-4'-Methyl-3'-(phenylthio)(1-azabicyclo<2.2.2>octane)-3-spiro-2'-(dihydrofuran-5'-one) 
• 121133-09-3 (2RS,3RS,3'SR)-2-Methyl-3-(3'-phenylthio-1'-azabicyclo<2.2.2>octan-3'-yl)propan-1,3-diol 
• 121133-11-7 Benzoic acid (2R,3R)-3-hydroxy-2-methyl-3-(3-phenylsulfanyl-1-aza-bicyclo[2.2.2]oct-3-yl)-propyl ester 
• 121133-13-9 (2S,3R)-3-(1-Aza-bicyclo[2.2.2]oct-2-en-3-yl)-2-methyl-3-phenylsulfanyl-propan-1-ol 
• 121133-10-6 C₁₇H₂₃NOS 
• 121160-46-1 C₁₇H₂₁NO₂S 
• 121133-09-3 (1R,2R)-2-Methyl-1-(3-phenylsulfanyl-1-aza-bicyclo[2.2.2]oct-3-yl)-propane-1,3-diol 

Relevant academic research and scientific papers

Stereospecific Phenylthio Migrations in the Synthesis of Spirocyclic Lactones and Ethers from N-Methyl-4-Piperidone and Quinuclidin-3-one

Single diastereoisomers of spirocyclic lactones and ethers have been prepared using intramolecular attack by the oxygen atom of a hydroxy or ester group onto an episulfonium ion.The sulfur group migrates with complete stereospecificity to give the saturat

STEREOCHEMICALLY CONTROLLED SYNTHESIS OF SPIROCYCLIC LACTONES AND ETHERS FROM N-METHYL-4-PIPERIDONE AND 3-QUINUCLIDINONE BY PHENYLTHIO MIGRATION

Phenylthio migration coupled to stereoselective aldol reactions provides single diastereoisomers of allylic sulphides and spirocyclic tetrahydrofurans and butenolides based on the piperidine and quinuclidine skeletons.