121133-75-3Relevant academic research and scientific papers
Enzymatic Preparation of N-Substituted 4-O-&α-D-Glucopyranosylmoranoline Derivatives
Ezure, Yohji,Maruo, Shigeaki,Ojima, Nobutoshi,Konno, Kiyotaka,Yamashita, Hiroshi,et al.
, p. 61 - 68 (2007/10/02)
A transglycosylation reaction with N-substituted moranolines was carried out with soluble starch as the glucose donor and cyclodextrin glycosyltransferase from Bacillus stearothermophilus, the degree of N-substituted moranolines that were converted to transglycosylation products being within the range of 60 to 81percent.The resultant transglycosylation products were hydrolyzed by glucoamylase from Rhisopus niveus, and the degree of N-substituted moranolines that were converted to N-substituted 4-O-α-D-glucopyranosylmoranolines was within the range of 53 to 72percent.The inhibitory activities of N-substituted 4-O-α-D-glucopyranosylmoranolines against cyclodextrin glycosyltransferase were greater than those of corresponding N-substituted moranolines, and N-substituted 4-O-α-D-glucopyranosylmoranolines lost the inhibitory activities against glucoamylase.Among these N-substituted 4-O-α-D-glucopyranosylmoranolines, the N-methyl derivative was a very potent inhibitor.
