121137-72-2

Upstream product

• 1011-46-7 6-phenyl-2,3,4,5-tetrahydropyridazin-3-one 
• 135-02-4 ortho-anisaldehyde 
• 1619970-79-4 (E)-ethyl 2-(2-methoxybenzylidene)-4-oxo-4-phenylbutanoate 

Downstream Products

• 121137-74-4 2-Hydroxymethyl-4-(2-methoxy-benzyl)-6-phenyl-2H-pyridazin-3-one 
• 121137-83-5 6-phenyl-4-(2-methoxybenzyl)-3-chloropyridazine 
• 121137-85-7 Benzyl-[4-(2-methoxy-benzyl)-6-phenyl-pyridazin-3-yl]-amine 
• 121137-89-1 4-(2-methoxybenzyl)-6-phenylpyridazine-3(2H)-thione 
• 126778-57-2 mercuri-{(6-phenyl-pyridazin-3(2H)-one-4-yl)(2-methoxy-phenyl)methyl}acetate 
• 1377396-34-3 3-[2-(4-(2-methoxybenzyl)-6-phenylpyridazin-3-yl)hydrazono]-5-fluoroindolin-2-one 
• 1377396-31-0 3-[2-(4-(2-methoxybenzyl)-6-phenylpyridazin-3-yl)hydrazono]-5-nitroindolin-2-one 
• 1377396-28-5 3-[2-(4-(2-methoxybenzyl)-6-phenylpyridazin-3-yl)hydrazono]-5-methoxyindolin-2-one 
• 1377396-25-2 3-[2-(4-(2-methoxybenzyl)-6-phenylpyridazin-3-yl)hydrazono]-5-chloroindolin-2-one 
• 1377396-19-4 3-[2-(4-(2-methoxybenzyl)-6-phenylpyridazin-3-yl)hydrazono]-5-methylindolin-2-one 
• 876594-47-7 3-[2-(4-(2-methoxybenzyl)-6-phenylpyridazin-3-yl)hydrazono]indolin-2-one 
• 121137-91-5 4-(2-methoxybenzyl)-3-(methylthio)-6-phenylpyridazine 
• 121137-81-3 2-(2'-cyanoethyl)-4-(o-methoxyphenylmethyl)-6-phenylpyridazin-3(2H)one 
• 121137-78-8 4-(2-Methoxy-benzyl)-2-morpholin-4-ylmethyl-6-phenyl-2H-pyridazin-3-one 

Relevant academic research and scientific papers

Synthesis of multi-functional alkenes via Wittig reaction with a new-type of phosphorus ylides

A Bu3P-mediated mild and efficient synthesis of multi-functional alkenes has been described starting from substituted acrylate with aldehydes. In situ generated zwitterionic intermediates underwent proton-exchange to afford ylide intermediates, which were trapped by corresponding aldehydes providing the products in up to 92% yield with complete E-stereoselectivity. Further derivatization of the products was performed to furnish functional pyridazinones.

Synthesis of multi-functional alkenes via Wittig reaction with a new-type of phosphorus ylides

A Bu3P-mediated mild and efficient synthesis of multi-functional alkenes has been described starting from substituted acrylate with aldehydes. In situ generated zwitterionic intermediates underwent proton-exchange to afford ylide intermediates, which were trapped by corresponding aldehydes providing the products in up to 92% yield with complete E-stereoselectivity. Further derivatization of the products was performed to furnish functional pyridazinones.

Antiproliferative effects of metal complexes of new isatin hydrazones against HCT116, MCF7 and HELA tumour cell lines

New hydrazone ligands (HL) derived from 5-substituted isatins and 1-(4-(2-methoxybenzyl)-6-arylpyridazin-3-yl)hydrazines and its complexes with Co(II) and Cu(II) were synthesized. The new hydrazones and their complexes were characterized by means of eleme

SYNTHESIS OF 6-ARYL-4-(o-METHOXYPHENYLMETHYL PYRIDAZINES AND SOME DERIVATIVES

6-Aryl-4,5-dihydro-3(2H)pyridazinones (1a,b) undergo base-catalyzed condensation with o-methoxybenzaldehyde, as an example of deactivated aldehydes, to give 6-aryl-4(o-methoxyphenylmethyl)pyridazin-3(2H)-ones (3a,b) in moderate yields.The reactions of the