1211480-91-9Relevant academic research and scientific papers
Synthesis of polycyclic nitrogen heterocycles via alkene aminopalladation/carbopalladation cascade reaction
Schultz, Danielle M.,Wolfe, John P.
supporting information; experimental part, p. 1028 - 1031 (2010/06/15)
Chemical equation presented A new method for the synthesis of tricyclic nitrogen heterocycles from N/,2-diallylaniline derivatives Is described. These transformations proceed via sequential alkene amlnopalladation of an Intermediate LnPd(Ar)(NRR') species followed by alkene carbopalladatlon of the resulting LnPd(Ar)(R) complex. Both alkene insertion steps occur in preference to C-N or C-C bond-forming reductive elimination. An unusual 1,3palladium shift occurs when 2-Allyl-N-(2-vinylphenyl) aniline Is employed as substrate, which yields a tetracyclic molecule with three contiguous stereocenters.
