1211539-36-4 Usage
General Description
Methyl 4-chloro-6-(trifluoromethyl)nicotinate, also known as TFMN, is a chemical compound with a molecular formula C9H6ClF3NO2. It is a derivative of nicotinic acid and belongs to the class of organic compounds known as nicotinate esters. TFMN is commonly used in the pharmaceutical industry for the synthesis of various drugs and compounds. It possesses unique properties such as being a potent inhibitor of the human DEFB1 and DEFB4A genes, making it potentially useful for the treatment of various diseases and disorders. Additionally, TFMN has been used as a building block in the development of novel agrochemicals and biomaterials. Overall, TFMN is a versatile chemical with potential applications in pharmaceuticals, agrochemicals, and other industries.
Check Digit Verification of cas no
The CAS Registry Mumber 1211539-36-4 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,1,1,5,3 and 9 respectively; the second part has 2 digits, 3 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 1211539-36:
(9*1)+(8*2)+(7*1)+(6*1)+(5*5)+(4*3)+(3*9)+(2*3)+(1*6)=114
114 % 10 = 4
So 1211539-36-4 is a valid CAS Registry Number.
1211539-36-4Relevant articles and documents
THIADIAZOLYL DERIVATIVES AS DNA POLYMERASE THETA INHIBITORS
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Paragraph 0530, (2020/12/11)
Disclosed herein are certain thiadiazolyl derivatives Formula (I): that inhibit DNA Polymerase Theta (Polθ) activity, in particular inhibit Polθ activity by inhibiting ATP dependent helicase domain activity of Polθ. Also, disclosed are pharmaceutical compositions comprising such compounds and methods of treating and/or preventing diseases treatable by inhibition of Polθ such as cancer, including homologous recombination (HR) deficient cancers.
