1211548-76-3Relevant academic research and scientific papers
Electrogenerated chemiluminescence of triazole-modified deoxycytidine analogues in N,N-dimethylformamide
Swanick, Kalen N.,Dodd, David W.,Price, Jacquelyn T.,Brazeau, Allison L.,Jones, Nathan D.,Hudson, Robert H. E.,Ding, Zhifeng
experimental part, p. 17405 - 17412 (2012/01/13)
Triazole-modified deoxycytidines have been prepared for incorporation into single-stranded deoxyribonucleic acid (ssDNA). Electrochemical responses and electrogenerated chemiluminescence (ECL) of these deoxycytidine (dC) analogues, 1-4, were investigated as the monomers. Cyclic voltammetry and differential pulse voltammetry techniques were used to determine the oxidation and reduction potentials of 1-4, along with the reversibility of their electrochemical reactions. The dC analogues, in N,N-dimethylformamide containing 0.1 M tetra-n-butylammonium perchlorate as electrolyte, exhibited weak relative ECL efficiencies following the annihilation mechanism, while these efficiencies were enhanced with the use of benzoyl peroxide following the coreactant mechanism. It was shown that these nucleosides could generate excited monomers, and excimers as seen by the red-shifted ECL maxima relative to their corresponding photoluminescence peak wavelengths.
Blue fluorescent deoxycytidine analogues: Convergent synthesis, solid-state and electronic structure, and solvatochromism
Dodd, David W.,Swanick, Kalen N.,Price, Jacquelyn T.,Brazeau, Allison L.,Ferguson,Jones, Nathan D.,Hudson, Robert H. E.
supporting information; experimental part, p. 663 - 666 (2010/05/11)
We report the synthesis and photospectroscopic characterisation of intrinsically fluorescent triazole-appended cytidines. Fluorescence was found to be highly dependent on solvent conditions. X-Ray crystallographic data show the proton of the exocyclic amine of the nucleobase and the triazole N3 engaged in a H-bond.
