1211586-09-2

Basic information

• Product Name: 6-Amino-2-aza-spiro[3.3]heptane-2-carboxylic acid tert-butyl ester
• Synonyms: tert-Butyl 6-amino-2-azaspiro[3.3]heptane-2-carboxylate, 6-Amino-2-(tert-butoxycarbonyl)-2-azaspiro[3.3]heptane;6-Amino-2-aza-spiro[3.3]heptane-2-carboxylic acid tert-butyl ester;6-amino-2-aza-spiro[3.3]h...;2-Boc-6-AMino-2-aza-spiro[3.3]heptane;tert-butyl 6-aMino-2-azaspiro[3.3]heptane-2-carboxylate;tert-butyl 2-aMino-6-azaspiro[3.3]heptane-6-carboxylate;6-Amino-2-azaspiro[3.3]heptane, N2-BOC protected
• CAS NO: 1211586-09-2
• Molecular Formula: C₁₁H₂₀N₂O₂
• Molecular Weight: 212.2887
• EINECS: 1592732-453-0
• Mol File: 1211586-09-2.mol
• Article Data: 4

Chemical Properties

• Melting Point: 115℃
• Boiling Point: 300.7±42.0 °C(Predicted)
• Appearance: /
• Density: 1.12
• Storage Temp.: 2-8°C(protect from light)
• PKA: 10.26±0.20(Predicted)
• CAS DataBase Reference: 6-Amino-2-aza-spiro[3.3]heptane-2-carboxylic acid tert-butyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 6-Amino-2-aza-spiro[3.3]heptane-2-carboxylic acid tert-butyl ester(1211586-09-2)
• EPA Substance Registry System: 6-Amino-2-aza-spiro[3.3]heptane-2-carboxylic acid tert-butyl ester(1211586-09-2)

Safety Data

• Hazardous Substances Data: 1211586-09-2(Hazardous Substances Data)

Usage

General Description

6-Amino-2-aza-spiro[3.3]heptane-2-carboxylic acid tert-butyl ester is a chemical compound that contains an aza-spiro ring system and a tert-butyl ester functional group. It is a spirocyclic compound that is commonly used as a building block in organic synthesis and drug discovery. The compound is a derivative of amines and carboxylic acids, with the tert-butyl ester group providing increased stability and lipophilicity. This makes it a useful precursor for the synthesis of pharmaceuticals and agrochemicals, as well as a potential ligand in coordination chemistry. Additionally, its unique spirocyclic structure makes it of interest in the development of novel chemical structures for various applications.

Upstream product

• 1181816-12-5 6-oxo-2-aza-spiro[3.3]heptane-2-carboxylic acid tert-butyl ester 
• 1239589-54-8 C₁₉H₂₆N₂O₄ 
• 1239320-12-7 tert-butyl 6-azido-2-azaspiro[3.3]heptane-2-carboxylate 
• 1239320-11-6 tert-butyl 6-((methylsulfonyl)oxy)-2-azaspiro[3.3]heptane-2-carboxylate 
• 1147557-97-8 6-hydroxy-2-aza-spiro[3.3]heptane-2-carboxylic acid tert-butyl ester 

Downstream Products

• 1415822-43-3 1-{6-[6-amino-5-(4-phenoxy-phenyl)-pyrimidin-4-ylamino]-2-aza-spiro[3.3]hept-2-yl}-propenone 

Relevant articles and documents

B-LACTAMASE INHIBITOR AND APPLICATION THEREOF

The present invention relates to a compound of Formula (I)-(IV) useful as β-lactamase inhibitor, a pharmaceutically acceptable salt, ester, solvate or stereoisomer thereof, wherein R1, R2, M and ring A have definitions as those in the specification. The present invention further relates to methods for preparing these compounds, pharmaceutical compositions comprising these compounds, and uses of these compounds. For example, the compounds of the present invention can be used as β-lactamase inhibitors, for treatment and/or prophylaxis of diseases caused by bacterial infections, solving drug-resistance problems caused by β-lactamases, especially bacterial drug-resistant diseases caused by type B metallo-β-lactamases.

DERIVATIVES OF AZASPIRANYL-ALKYLCARBAMATES OF 5-MEMBER HETEROCYCLIC COMPOUNDS, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF

The invention relates to a compound of the general formula (I) in which R2 is a hydrogen or fluorine atom or a hydroxyl, cyano, trifluoromethyl, C1-6-alkyl, C1-6-alkoxy, NR8R9 group; m, n, o and p are independently an integer equal to 0, 1, 2 or 3; A is a covalent bond or a C1-8-alkylene group; R1 is an optionally substituted aryl or heteroaryl group; R3 is a hydrogen or fluorine atom or a C1-6-alkyl group or a trifluoromethyl group; R4 is an optionally substituted 5-member heterocyclic compound; the compound being in the form of a base or acid addition salt. The invention also relates to the therapeutic use thereof.