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1211866-85-1

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  • AcetaMide, N-[2-Methyl-3-[[4-[4-[[4-(trifluoroMethoxy)phenyl]Methoxy]-1-piperidinyl]-1,3,5-triazin-2-yl]aMino]phenyl]-

    Cas No: 1211866-85-1

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1211866-85-1 Usage

Uses

TC-N 1752 is a potent, state-dependent inhibitor of Nav1.7, which is a neuronal voltage gated sodium channel and a critical mediator of pain sensitization.

Check Digit Verification of cas no

The CAS Registry Mumber 1211866-85-1 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,1,1,8,6 and 6 respectively; the second part has 2 digits, 8 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 1211866-85:
(9*1)+(8*2)+(7*1)+(6*1)+(5*8)+(4*6)+(3*6)+(2*8)+(1*5)=141
141 % 10 = 1
So 1211866-85-1 is a valid CAS Registry Number.

1211866-85-1SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 20, 2017

Revision Date: Aug 20, 2017

1.Identification

1.1 GHS Product identifier

Product name N-(2-Methyl-3-{[4-(4-{[4-(trifluoromethoxy)benzyl]oxy}-1-piperidi nyl)-1,3,5-triazin-2-yl]amino}phenyl)acetamide

1.2 Other means of identification

Product number -
Other names Cyclohexanamine,N-(2-methyl-2-propenylidene)-,(E)

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:1211866-85-1 SDS

1211866-85-1Downstream Products

1211866-85-1Relevant articles and documents

Identification of a potent, state-dependent inhibitor of Nav1.7 with oral efficacy in the formalin model of persistent pain

Bregman, Howard,Berry, Loren,Buchanan, John L.,Chen, April,Du, Bingfan,Feric, Elma,Hierl, Markus,Huang, Liyue,Immke, David,Janosky, Brett,Johnson, Danielle,Li, Xingwen,Ligutti, Joseph,Liu, Dong,Malmberg, Annika,Matson, David,McDermott, Jeff,Miu, Peter,Nguyen, Hanh Nho,Patel, Vinod F.,Waldon, Daniel,Wilenkin, Ben,Zheng, Xiao Mei,Zou, Anruo,McDonough, Stefan I.,Dimauro, Erin F.

, p. 4427 - 4445 (2011/09/14)

Clinical human genetic studies have recently identified the tetrodotoxin (TTX) sensitive neuronal voltage gated sodium channel Nav1.7 (SCN9A) as a critical mediator of pain sensitization. Herein, we report structure-activity relationships for a novel series of 2,4-diaminotriazines that inhibit hNav1.7. Optimization efforts culminated in compound 52, which demonstrated pharmacokinetic properties appropriate for in vivo testing in rats. The binding site of compound 52 on Nav1.7 was determined to be distinct from that of local anesthetics. Compound 52 inhibited tetrodotoxin-sensitive sodium channels recorded from rat sensory neurons and exhibited modest selectivity against the hERG potassium channel and against cloned and native tetrodotoxin-resistant sodium channels. Upon oral administration to rats, compound 52 produced dose- and exposure-dependent efficacy in the formalin model of pain.

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