1211936-80-9Relevant academic research and scientific papers
Combined rhodium-catalyzed carbon-hydrogen activation and β-carbon elimination to access eight-membered rings
Crepin, Damien,Dawick, James,Aissa, Lhnstopne
supporting information; experimental part, p. 620 - 623 (2010/04/05)
(Figure Presented) Enlargel C-H bond activation and β-carbon elimination are combined in a net intramolecular hydroacylation of alkylidenecyclobutanes and alkylideneazetidines in the presence of rhodium catalysts, affording eight-membered-ring compounds in high yield (see scheme). This study demonstrates the possibility of exploiting the strain energy of azetidines through β-carbon elimination in new transition-metal-catalyzed reactions.
