121195-63-9Relevant academic research and scientific papers
Quinine as an organocatalytic dual activator for the diastereoselective synthesis of spiro-epoxyoxindoles
Chouhan, Mangilal,Pal, Anang,Sharma, Ratnesh,Nair, Vipin A.
supporting information, p. 7119 - 7123 (2013/12/04)
A highly efficient organocatalytic approach has been developed for the diastereoselective epoxidation of (E)-3-ylidene-indolin-2-one derivatives using readily available natural product quinine and urea-hydrogen peroxide (UHP) in DCM at 10 C to afford trans spiro-epoxyoxindoles which were further utilized to obtain β-hydroxy-α-amino esters by water mediated regioselective ring opening from the less hindered end with aniline derivatives, under sonication.
A New Synthesis of some Indolecarboxylic Acids
Baiocchi, Leandro,Giannangeli, Marilena
, p. 1905 - 1909 (2007/10/02)
1-Substituted isatins are transformed into indole derivatives by means of ethyl chloroacetate.In fact, under the conditions of the Darzens reaction they give two glycidic ester isomers 4 and 5 which, by hydrolysis in alkaline medium, undergo a transposition to indole-2,3-dicarboxylic acids 2 together with minor amounts of indole-3-carboxylic acids 3.From isatin itself, 2,3-dicarboxyindole-1-acetic acid (6) was obtained.
