121206-76-6

Basic information

• Product Name: 5-BROMO-3-(1-METHYL-4-PIPERIDINYL)INDOLE
• Synonyms: 5-BROMO-3-(1-METHYL-4-PIPERIDINYL)INDOLE;1H-Indole, 5-broMo-3-(1-Methyl-4-piperidinyl)-
• CAS NO: 121206-76-6
• Molecular Formula: C₁₄H₁₇BrN₂
• Molecular Weight: 293.2
• Product Categories: pharmacetical
• Mol File: 121206-76-6.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 421.2°Cat760mmHg
• Flash Point: 208.5°C
• Appearance: /
• Density: 1.394g/cm³
• Vapor Pressure: 2.65E-07mmHg at 25°C
• Refractive Index: 1.639
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 5-BROMO-3-(1-METHYL-4-PIPERIDINYL)INDOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-BROMO-3-(1-METHYL-4-PIPERIDINYL)INDOLE(121206-76-6)
• EPA Substance Registry System: 5-BROMO-3-(1-METHYL-4-PIPERIDINYL)INDOLE(121206-76-6)

Safety Data

• Hazardous Substances Data: 121206-76-6(Hazardous Substances Data)

Usage

Chemical Properties

white powder

InChI:InChI=1/C14H17BrN2/c1-17-6-4-10(5-7-17)13-9-16-14-3-2-11(15)8-12(13)14/h2-3,8-10,16H,4-7H2,1H3

Upstream product

• 1445-73-4 1-Methyl-4-piperidone 
• 10075-50-0 5-bromo-1H-indole 
• 116480-53-6 5-bromo-3-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)-1H-indole 
• 13669-28-8 1-methyl-4-methylene-1-azacyclohexane 
• 201230-82-2 carbon monoxide 
• 589-21-9 (4-bromophenyl)hydrazine 

Downstream Products

• 253439-64-4 5-(4-Aminophenyl)-3-(1-Methylpiperidin-4-yl)-1H-Indole 
• 253439-62-2 5-(4-Acetylphenyl)-3-(1-Methylpiperidin-4-yl)-1H-Indole 
• 253439-61-1 5-(4-Acetamidophenyl)-3-(1-Methylpiperidin-4-yl)-1H-Indole 
• 253439-68-8 5-phenyl-3-(1-methylpiperidin-4-yl)-1-(triisopropylsilyl)-indole 
• 253439-70-2 5-(4-methoxyphenyl)-3-(1-methylpiperidin-4-yl)-1-(triisopropylsilyl)-indole 
• 253439-59-7 5-(4-(4-Fluorobenzamido)phenyl)-3-(1-Methylpiperidin-4-yl)-1H-Indole 

Relevant articles and documents

Novel chemoselective reduction of the tetrahydro-4-pyridyl versus indole moiety governed by electron donation: First X-ray evidence for indolopiperidyl-borane complexation

A series of amino-borane complexes of structure type 2 are the key intermediates in the preparation of 3-(piperidyl) indole derivatives. The selective reduction of the tetrahydro-4-pyridyl double bond via 2 under strongly acidic conditions is feasible only when the pyridyl double bond is conjugated with electron rich substituents, such as indoles. This reduction methodology allows the presence of reducible and hydrogenolizable functional groups. An improved process to prepare 2 by treatment of the 3-(tetrahydro-4-pyridyl) indole derivatives with NaBH4 in THF under acidic conditions (AcOH or CF3COOH) is also described.

Synthesis of pharmacologically relevant indoles with amine side chains via tandem hydroformylation/fischer indole synthesis

The sequence of hydroformylation and Fischer indole synthesis starting from amino olefins and aryl hydrazines is described. In a convergent manner, the two units bearing pharmacologically relevant substituents are assembled in the final indolization step. This modular and diversity-oriented approach to tryptamines and homotryptamines can be conducted in water and allows synthesis of branched and nonbranched tryptamines as well as tryptamine-based pharmaceuticals such as the 5-HT1D agonist L 775 606.

Indazole derivatives as 5-HT1F agonists

The present invention relates to a compound of formula or a pharmaceutical acid addition salt thereof; which are useful for activating 5-HT1F receptors and inhibiting neuronal protein extravasation in a mammal.