121217-65-0

Basic information

• Product Name: 2-amino-N-benzylquinoline-3-carboxamide
• Synonyms: 2-amino-N-benzylquinoline-3-carboxamide
• CAS NO: 121217-65-0
• Molecular Weight: 277.326
• Mol File: 121217-65-0.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 2-amino-N-benzylquinoline-3-carboxamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-amino-N-benzylquinoline-3-carboxamide(121217-65-0)
• EPA Substance Registry System: 2-amino-N-benzylquinoline-3-carboxamide(121217-65-0)

Safety Data

• Hazardous Substances Data: 121217-65-0(Hazardous Substances Data)

Upstream product

• 10412-93-8 N-Benzylcyanoacetamide 
• 6630-33-7 ortho-bromobenzaldehyde 
• 552-89-6 2-nitro-benzaldehyde 
• 121217-56-9 (Z)-N-Benzyl-2-cyano-3-(2-nitro-phenyl)-acrylamide 

Relevant articles and documents

Synthesis of 2-aminoquinoline-3-carboamides and pyrimido[4,5-b]quinolin-4-ones through copper-catalyzed one-pot multicomponent reactions

Pyrimido[4,5-b]quinolinones have attracted considerable interest from both chemical and medicinal scientists as these compounds display remarkable antimicrobial, anti-inflammatory, antitumor, antiallergy, analgesic, and antioxidant activities. The importance of pyrimido[4,5-b]quinolinones has stimulated enormous efforts to develop efficient methodologies for their synthesis. Herein, we disclose a novel synthetic protocol toward pyrimido[4,5-b]quinolin-4-ones through Cu(OAc)2-catalyzed one-pot four-component reactions of 2-bromobenzaldehydes, aqueous ammonia, cyanoacetamides and aldehydes. The synthetic procedure combines amination/condensation/cyclization/dehydrogenation reactions in one pot, allowing synthesis of complex compounds in a simple and practical manner. Compared with literature procedures, the synthetic strategies developed herein showed advantages such as readily available and economically sustainable starting materials, structural diversity of products, good functional group tolerance, and a remarkably simple operation process.

SYNTHESIS OF SUBSTITUTED 2-AMINOQUINOLINE-3-CARBOXYLIC ACID AMIDES

Substituted 3-(2-nitrophenyl)-2-cyanoacrylic acid amides were synthesized by the Knoevenagel reaction and were then reduced with iron in acetic acid to the corresponding 2-aminoquinoline-3-carboxylic acid amides.