121219-16-7

Basic information

• Product Name: 2,3-Difluorophenylboronic acid
• Synonyms: RARECHEM AH PB 0166;2,3-DIFLUOROPHENYLBORONIC ACID;2,3-DIFLUOROBENZENEBORONIC ACID;2,3-FLUOROBENZENE BORONIC ACID;2,3-Difluorophenylboronic acid, 97+%;2,3-Difluorobenzeneboronic acid 98%;2,3-Difluorobenzeneboronicacid98%;2,3-Difluorophenylboronic Acid (contains varying amounts of Anhydride)
• CAS NO: 121219-16-7
• Molecular Formula: C₆H₅BF₂O₂
• Molecular Weight: 157.91
• EINECS: -0
• Product Categories: blocks;BoronicAcids;FluoroCompounds;Boric Acid;Fluorobenzene;Boronic Acid;Aryl;Halogenated;Organoborons;B (Classes of Boron Compounds);Boronic Acids;Boronic Acids;Boronic Acids and Derivatives;Boronate Ester;Potassium Trifluoroborate
• Mol File: 121219-16-7.mol
• Article Data: 16

Chemical Properties

• Melting Point: 95 °C (dec.)(lit.)
• Boiling Point: 274.8 ºC at 760 mmHg
• Flash Point: 120ºC
• Appearance: White to light beige/Crystalline Powder
• Density: 1.35 g/cm³
• Vapor Pressure: 0.00257mmHg at 25°C
• Refractive Index: 1.485
• Storage Temp.: 0-6°C
• Solubility: soluble in Methanol
• PKA: 7.29±0.58(Predicted)
• BRN: 6594341
• CAS DataBase Reference: 2,3-Difluorophenylboronic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2,3-Difluorophenylboronic acid(121219-16-7)
• EPA Substance Registry System: 2,3-Difluorophenylboronic acid(121219-16-7)

Safety Data

• Hazard Codes: Xn,Xi
• Statements: 36/37/38-22
• Safety Statements: 37/39-26-36/37
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 121219-16-7(Hazardous Substances Data)

Usage

Chemical Properties

Off-white to light beige crystalline powder

Uses

Different sources of media describe the Uses of 121219-16-7 differently. You can refer to the following data:
1. suzuki reaction
2. 2,3-Difluorophenylboronic acid is a useful reagent for the preparation of pharmaceutical and biologically active molecules.
3. Intermediates of Liquid Crystals

InChI:InChI=1/C6H5BF2O2/c8-5-3-1-2-4(6(5)9)7(10)11/h1-3,10-11H

Upstream product

• 121-43-7 Trimethyl borate 
• 367-11-3 ortho-difluorobenzene 
• 688-71-1 tri-n-propyl borate 
• 109-72-8 n-butyllithium 
• 5419-55-6 Triisopropyl borate 
• 33863-76-2 1-bromo-3-chloro-5-fluorobenzene 

Downstream Products

• 880144-45-6 benzyl (5S)-N,N-bis(tert-butoxycarbonyl)-5-(2,3-difluorophenyl)-6-nitro-D-norleucinate 
• 781650-29-1 benzyl (1R)-1-{[[2-(2,3-difluorophenyl)prop-2-enyl](2,4-dimethoxybenzyl)amino]carbonyl}but-3-enylcarbamate 
• 784156-87-2 5-(2,3-difluorophenyl)-1-(2-methoxyethyl)-3-nitropyridin-2(1H)-one 
• 313671-56-6 tert-butyl (8AS,12AR)-2-(2,3-difluorophenyl)-4,5,6,7,8a,9,10,11,12,12a-decahydroazepino[3,2,1-hi]pyrido[4,3-b]indole-11(8AH)-carboxylate 
• 313671-88-4 tert-butyl (7AS,11AR)-2-(2,3-difluorophenyl)-5,6,7a,8,9,10,11,11a-octahydro-4H-pyrido[3',4':4,5]pyrrolo[3,2,1-ij]quinoline-10(7AH)-carboxylate 
• 952238-15-2 2-[6-(2,3-difluorophenyl)-5-(methylpyridin-2-yl)]-7,8-dihydro-5H-pyrano-[4,3-d]-pyrimidine 
• 1144519-95-8 C₁₇H₂₀F₂N₂O₃ 
• 1160854-18-1 C₂₀H₁₆F₂N₆ 
• 121219-17-8 2,3-difluoro-4'-pentylbiphenyl 
• 1428619-96-8 2-[6-(2,3-difluorophenyl)-2-(4-methylbenzoylimino)benzo[d]thiazol-3(2H)-yl]butanoic acid 
• 1439364-54-1 3-(2',3'-difluorophenyl)pyrazine-2-carbonitrile 
• 1452520-31-8 2-({4-[({[5-(2,3-difluorophenyl)-1H-indazol-3-yl]carbonyl}amino)methyl]piperidin-1-yl}methyl)-1,3-oxazole-4-carboxylic acid 
• 1414356-56-1 3-[(3R)-3-[4-amino-3-[4-(2,3-difluorophenoxy)phenyl]-1H-pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl]-3-oxopropanenitrile 
• 1414356-53-8 (R)-2-(3-(4-amino-3-(4-(2,3-difluorophenoxy)phenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidine-1-carbonyl)-3-cyclopropylacrylonitrile 

Relevant articles and documents

Enhancing charge mobilities in selectively fluorinated oligophenyl organic semiconductors: a design approach based on experimental and computational perspectives

Fluorination can be used to tune optoelectronic properties at the molecular level. A series of oligophenyls with various difluorinations of the phenyl rings has been synthesized, crystalized, structurally resolved and computationally analyzed for charge m

Liquid crystal carbonate and liquid crystal medium containing the same with positive or negative dielectric anisotropy

A novel liquid crystalline carbonate and the mixture containing the same: wherein R3 is an alkyl (H2n+1Cn) or an alkenyl (H2n?1Cn) group, each of 1 to 12 carbon atoms, the ring A is laterally unsubstituted benze

New SmCG phases in a hydrogen-bonded bent-core liquid crystal featuring a branched siloxane terminal group

In this study, we synthesized three analogous bent-core molecules, a hydrogen-bonded complex and a covalent-bonded compound with branched siloxane units (H-SiO and C-SiO, respectively) and a hydrogen-bonded complex with an alkyl unit (H-Alk), and investigated the effects of the hydrogen bonding and branched siloxane terminal units on their mesomorphic properties. The covalent-bonded compound C-SiO and the hydrogen-bonded complex H-Alk exhibited typical SmCP phases; in contrast, the hydrogen-bonded complex H-SiO exhibited a series of general tilt smectic (SmCG) phases with highly ordered layer structures (i.e., SmCG2PF-USmCG2P A-SmCG2PF-SmCGPF upon cooling). During the SmCG-type phase transition process, a 2D-modulated ribbon structure transferred into highly ordered layers via undulated layers, as the hydrogen-bonding strength increased with reduced temperatures. As the SmCG domains were aligned under dc electric fields, a gradual decrease in the leaning angle from ca. 60° to 50° (while the tilt angle kept at ca. 31°) could be determined by in situ wide-angle X-ray scattering (WAXS). Combined with Fourier transform infrared and Raman spectroscopic data, our results suggest that the change in the leaning angle was governed by the competition of the hydrogen bonds and microsegregation of siloxane units within the bilayer structure of the hydrogen-bonded complex H-SiO. In addition, the ferroelectric-(antiferroelectric)-ferroelectric transitions proven by the switching current responses in the SmCG-type phases of H-SiO reveal that the polar switching occurred through collective rotations around the long axis of H-SiO. Therefore, novel SmCG phases with a series of highly ordered 2D-structures were induced by the effects of the hydrogen bonding and branched terminal siloxane unit in the bent-core hydrogen-bonded LC complex H-SiO.