1212264-66-8

Basic information

• Product Name: (1S)-N-{1-[3-(trifluoromethyl)phenyl]ethyl}methylamine
• Synonyms: (1S)-N-{1-[3-(trifluoromethyl)phenyl]ethyl}methylamine;(1S)-N-Methyl-1-[3-(trifluoromethyl)phenyl]ethylamine
• CAS NO: 1212264-66-8
• Molecular Formula: C10H12F3N
• Molecular Weight: 203.2041896
• Mol File: 1212264-66-8.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (1S)-N-{1-[3-(trifluoromethyl)phenyl]ethyl}methylamine(CAS DataBase Reference)
• NIST Chemistry Reference: (1S)-N-{1-[3-(trifluoromethyl)phenyl]ethyl}methylamine(1212264-66-8)
• EPA Substance Registry System: (1S)-N-{1-[3-(trifluoromethyl)phenyl]ethyl}methylamine(1212264-66-8)

Safety Data

• Hazardous Substances Data: 1212264-66-8(Hazardous Substances Data)

Usage

General Description

"(1S)-N-{1-[3-(trifluoromethyl)phenyl]ethyl}methylamine" is a chemical compound with a molecular formula C11H14F3N. It is a chiral amine compound with a stereocenter at the nitrogen atom, meaning it has two enantiomers. (1S)-N-{1-[3-(trifluoromethyl)phenyl]ethyl}methylamine is commonly used as a building block in organic synthesis and pharmaceutical research. It is also known for its potential pharmacological properties, making it an important intermediate for the development of various pharmaceutical drugs. The presence of both an amine and a trifluoromethyl group in its structure makes it a versatile and valuable compound in the field of medicinal chemistry.

Upstream product

• 349-76-8 3'-(trifluoromethyl)acetophenone 
• 118797-81-2 N-methyl-[1-(3'-trifluoromethylphenyl)ethylidene]amine 
• 1446770-93-9 tert-butyl N-[(1R)-1-[3-(trifluoromethyl)phenyl]ethyl]carbamate 
• 127852-30-6 (R)-α-(m-(trifluoromethyl)phenyl)ethylamine 

Downstream Products

• 1453069-99-2 (1S,8aS)-7,7-diallyl-N-methyl-6-oxo-1-o-tolyl-N-((R)-1-(3-(trifluoromethyl)phenyl)ethyl)hexahydropyrrolo[1,2-a]pyrazine-2(1H)-carboxamide 

Relevant articles and documents

Tackling N-Alkyl Imines with 3d Metal Catalysis: Highly Enantioselective Iron-Catalyzed Synthesis of α-Chiral Amines

A readily activated iron alkyl precatalyst effectively catalyzes the highly enantioselective hydroboration of N-alkyl imines. Employing a chiral bis(oxazolinylmethylidene)isoindoline pincer ligand, the asymmetric reduction of various acyclic N-alkyl imines provided the corresponding α-chiral amines in excellent yields and with up to >99 % ee. The applicability of this base metal catalytic system was further demonstrated with the synthesis of the pharmaceuticals Fendiline and Tecalcet.

BENZIMIDAZOLYL-ACETAMIDE DERIVATIVES USEFUL AS POTASSIUM CHANNEL MODULATORS

This invention relates to novel benzimidazolyl-acetamide derivatives to formula (l) and their use as modulators of small-conductance calcium-activated potassium channels (SK channels). Moreover the invention is directed to pharmaceutical compositions useful for the treatment or alleviation of diseases or disorders associated with the activity of potassium channels.