1212413-55-2Relevant academic research and scientific papers
NOVEL BETULINIC SUBSTITUTED AMIDE DERIVATIVES AS HIV INHIBITORS
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, (2017/02/24)
The present invention relates to novel betulinic substituted amide compounds of formula (I); and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, R5, R6, R7, R8, X, Y, Z1, Z2, Z3 and are Formula (II) as defined herein. The invention novel betulinic substituted amide derivatives, related compounds, and pharmaceutical compositions useful for the therapeutic treatment of viral diseases and particularly HIV mediated diseases.
Discovery of highly potent and selective pan-Aurora kinase inhibitors with enhanced in vivo antitumor therapeutic index
Liu, Gang,Abraham, Sunny,Tran, Lan,Vickers, Troy D.,Xu, Shimin,Hadd, Michael J.,Quiambao, Sheena,Holladay, Mark W.,Hua, Helen,Ford Pulido, Julia M.,Gunawardane, Ruwanthi N.,Davis, Mindy I.,Eichelberger, Shawn R.,Apuy, Julius L.,Gitnick, Dana,Gardner, Michael F.,James, Joyce,Breider, Mike A.,Belli, Barbara,Armstrong, Robert C.,Treiber, Daniel K.
scheme or table, p. 3250 - 3260 (2012/06/01)
Serine/threonine protein kinases Aurora A, B, and C play essential roles in cell mitosis and cytokinesis. Currently a number of Aurora kinase inhibitors with different isoform selectivities are being evaluated in the clinic. Herein we report the discovery and characterization of 21c (AC014) and 21i (AC081), two structurally novel, potent, kinome-selective pan-Aurora inhibitors. In the human colon cancer cell line HCT-116, both compounds potently inhibit histone H3 phosphorylation and cell proliferation while inducing 8N polyploidy. Both compounds administered intravenously on intermittent schedules displayed potent and durable antitumor activity in a nude rat HCT-116 tumor xenograft model and exhibited good in vivo tolerability. Taken together, these data support further development of both 21c and 21i as potential therapeutic agents for the treatment of solid tumors and hematological malignancies.
