121246-91-1

Basic information

• Product Name: (3-CHLOROPYRAZIN-2-YL)(PHENYL)METHANONE
• Synonyms: (3-CHLOROPYRAZIN-2-YL)(PHENYL)METHANONE
• CAS NO: 121246-91-1
• Molecular Formula: C₁₁H₇ClN₂O
• Molecular Weight: 218.64
• Mol File: 121246-91-1.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (3-CHLOROPYRAZIN-2-YL)(PHENYL)METHANONE(CAS DataBase Reference)
• NIST Chemistry Reference: (3-CHLOROPYRAZIN-2-YL)(PHENYL)METHANONE(121246-91-1)
• EPA Substance Registry System: (3-CHLOROPYRAZIN-2-YL)(PHENYL)METHANONE(121246-91-1)

Safety Data

• Hazardous Substances Data: 121246-91-1(Hazardous Substances Data)

Usage

General Description

(3-Chloropyrazin-2-yl)(phenyl)methanone is a chemical compound with the molecular formula C12H8ClN2O. It is a white to off-white powder that is used as a building block in the synthesis of pharmaceuticals and agrochemicals. (3-CHLOROPYRAZIN-2-YL)(PHENYL)METHANONE is a ketone derivative with a chloropyrazine ring and a phenyl group, making it useful in various organic synthesis reactions. The presence of the chloropyrazine and phenyl groups gives the compound potential for biological and chemical activity, making it valuable in drug discovery and development. Overall, this compound has important applications in the pharmaceutical and agrochemical industries as a key intermediate in the synthesis of various compounds.

Upstream product

• 14508-49-7 2-chloropyrazin 
• 611-74-5 N,N-dimethylbenzamide 
• 121246-85-3 (3-chloropyrazin-2-yl)phenylmethanol 
• 6919-61-5 N-methoxy-N-methylbenzamide 
• 100-52-7 benzaldehyde 

Downstream Products

• 56414-03-0 2-benzoyl-3-aminopyrazine 
• 1248661-24-6 phenyl{3-[(trimethylsilyl)ethynyl]pyrazin-2-yl}methanone 
• 1248661-26-8 5-(2-oxopropyl)-7,9-diphenylpyrrolo[3,4-g]quinoxaline-6,8-dione 
• 1248661-28-0 (3-iodopyrazin-2-yl)phenylmethanone 

Relevant articles and documents

A convenient two-step synthesis of 7-aryl-6,7-dihydrothieno[2,3-b]pyrazines from aryl(3-chloropyrazin-2-yl)methanones

An efficient method for the preparation of 7-aryl-6,7-dihydrothieno[2,3-b] pyrazines (3) under mild conditions has been developed. The reaction of aryl(3-chloropyrazin-2-yl)methanones (1), derived from commercially available 2-chloropyrazine, with methylenetriphenylphosphorane in THF at room temperature gave the corresponding 2-(1-arylethenyl)-3-chloropyrazines (2), which were treated with NaSH?nH2O in DMF at room temperature to lead to the desired products (3) in acceptable yields. These products are dehydrogenated with air in refluxing toluene in the presence of a catalytic amount of Pd/C to yield the corresponding 7-arylthieno[2,3-b]pyrazines (4).

A New Route to 2,3-Disubstituted Pyrazines; Regioselective Metalation of Chloropyrazine

Chloropyrazine is regioselectively metalated by lithium amides in tetrahydrofuran to give 3-chloro-2-lithiopyrazine.The reaction of this lithio derivative with electrophiles can either be performed in situ (with the electrophile, e.g., chlorotrimethylsila