121256-16-4

Upstream product

• 95900-42-8 5'-O-dimethoxytrityl-N₄-toluyldeoxycitidine 
• 56183-63-2 bis(diisopropylamino)chlorophosphine 
• 121238-15-1 3'-O-phenoxyacetyl-N₄-toluyldeoxycitidine 
• 121238-14-0 C₅₀H₆₄N₅O₇P 

Downstream Products

• 121238-17-3 5'-O-dimethoxytrityl-N₄-toluyldeoxycytidinyl-3'-O-(5'-O-N₄-toluyldeoxycytidinyl)-S-(4-chlorobenzyl)phosphorodithioate 
• 121256-18-6 5'-O-dimethoxytrityl-N4-toluyldeoxycytidine-3'-O-(5'-O-N4-toluyldeoxycytidine-3'-O-β-cyanoethyl-N,N-diisopropylaminophosphine)-S-(4-chlorobenzyl)phosphorodithioate 
• 121256-17-5 5'-O-dimethoxytrityl-N₄-toluyldeoxycytidinyl-3'-O-(5'-O-N₄-toluyldeoxycytidine-3'-O-phenoxyacetyl)-S-(4-chlorobenzyl)phosphorodithioate 
• 121238-16-2 C₇₀H₆₆ClN₆O₁₄PS 

Relevant academic research and scientific papers

SYNTHESIS OF DEOXYCYTIDINE OLIGOMERS CONTAINING PHOSPHORODITHIOATE LINKAGES

Deoxydicytidine phosphoramidite, 4-chlorobenzylmercaptan and tetrazole reacted to form dinucleoside thiophosphite.Oxidation with sulfur yields phosphorodithioates which used to synthesize pentadecadeoxyoligonucleotides containing nuclease resistant phosphorodithioate internucleotide linkages.