121268-85-7Relevant academic research and scientific papers
Synthesis of 6-Substituted 7H-Pyridocarbazoles
Modi, Sandeep P.,Zayed, Abdel-Hadi,Archer, Sydney
, p. 3084 - 3087 (1989)
Condensation of N-(phenylsulfonyl)-2-methoxalylindole and its 5-methoxy analogue with a modified Wittig reagent prepared from diphenyl(4-pyridylmethyl)phosphine oxide furnished the olefins 16 and 17, respectively.Oxidative photocyclization furnished the 6-carbomethoxy-7H-pyridocarbazoles 18 and 24.Reduction with lithium aluminium hydride gave the carbinols 19 and 23, which when treated with methyl isocyanate gave the corresponding N-methylcarbamates 20 and 26, which are potential antitumor agents.Manganese dioxide oxidation of 19 and 25 furnished the aldehydes 21 and 27.Treatment with methylenetriphenylphosphorane gave olefins 22 and 28, which upon catalytic reduction afforded the 6-ethyl-7H-pyridocarbazoles 23 and the known 29.
