121269-48-5

Basic information

• Product Name: 4-Morpholinecarboxylic acid, 3-methyl-2-oxo-5-phenyl-, 1,1-dimethylethyl ester, (3R,5R)-
• CAS NO: 121269-48-5
• Molecular Formula: C16H21NO4
• Molecular Weight: 291.347
• Mol File: 121269-48-5.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 4-Morpholinecarboxylic acid, 3-methyl-2-oxo-5-phenyl-, 1,1-dimethylethyl ester, (3R,5R)-(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Morpholinecarboxylic acid, 3-methyl-2-oxo-5-phenyl-, 1,1-dimethylethyl ester, (3R,5R)-(121269-48-5)
• EPA Substance Registry System: 4-Morpholinecarboxylic acid, 3-methyl-2-oxo-5-phenyl-, 1,1-dimethylethyl ester, (3R,5R)-(121269-48-5)

Safety Data

• Hazardous Substances Data: 121269-48-5(Hazardous Substances Data)

Upstream product

• 56613-80-0 D-2-phenylglycinol 
• 119878-90-9 (5R)-4-(tert-butyloxycarbonyl)-5-phenyl-2,3,5,6-tetrahydro-4H-1,4-oxazin-2-one 
• 74-88-4 methyl iodide 
• 24424-99-5 di-tert-butyl dicarbonate 
• 121269-45-2 (R)-5-phenyl-3,4,5,6-tetrahydro-2H-1,4-oxazin-2-one 

Downstream Products

• 874368-20-4 (4R,9aR)-9a-Methyl-4-phenylhexahydropyrido<2,1-c><1,4>oxazin-1-one 
• 121348-76-3 (3S,5R)-2,3,5,6-tetrahydro-3-methyl-5-phenyl-N-(tert-butyloxycarbonyl)-4H-1,4-oxazin-2-one 

Relevant articles and documents

An efficient, asymmetric synthesis of pipecolic acid and 2-alkyl pipecolic acids

Both (R)- and (S)-pipecolic acids and their 2-alkyl derivatives have been synthesized via diastereoselective alkylations of (R)-5-phenylmorpholin-2-one 5.

STEREOSELECTIVE ALKYLATION OF CHIRAL GLYCINE ENOLATE SYNTHONS. THE ENANTIOSELECTIVE SYNTHESIS O α-AMINO ACID DERIVATES

The highly stereoselective alkylation (percentde=99.6 to 97.6) o a new chiral glycine enolate synthon derived from D-2-phenylglycinol is described.Deprotection of the alkylation adducts in a one-pot, three-step procedure provides the ethyl ester hydrochloride salts of the corresponding α-amino acids with no attending racemization.