1212716-22-7

Basic information

• Product Name: ((S)-2,2,2-TRIFLUORO-1-METHYLETHYL)BENZENE
• Synonyms: ((S)-2,2,2-TRIFLUORO-1-METHYLETHYL)BENZENE
• CAS NO: 1212716-22-7
• Molecular Formula: C9H9F3
• Molecular Weight: 174.16
• Mol File: 1212716-22-7.mol
• Article Data: 10

Chemical Properties

• Appearance: /
• CAS DataBase Reference: ((S)-2,2,2-TRIFLUORO-1-METHYLETHYL)BENZENE(CAS DataBase Reference)
• NIST Chemistry Reference: ((S)-2,2,2-TRIFLUORO-1-METHYLETHYL)BENZENE(1212716-22-7)
• EPA Substance Registry System: ((S)-2,2,2-TRIFLUORO-1-METHYLETHYL)BENZENE(1212716-22-7)

Safety Data

• Hazardous Substances Data: 1212716-22-7(Hazardous Substances Data)

Upstream product

• 92-81-9 acridine 
• 384-64-5 3,3,3-trifluoro-2-phenylpropene 
• 434-45-7 2,2,2-Trifluoroacetophenone 
• 1895006-01-5 dimesityl(trifluoromethyl)sulfonium trifluoromethanesulfonate 
• 585-71-7 (1-bromoethyl)benzne 
• 680-15-9 2,2-difluoro-2-(fluorosulfonyl)acetate 
• 98-85-1 1-Phenylethanol 

Relevant articles and documents

Highly Selective Hydrogenation of C═C Bonds Catalyzed by a Rhodium Hydride

Under mild conditions (room temperature, 80 psi of H2) Cp*Rh(2-(2-pyridyl)phenyl)H catalyzes the selective hydrogenation of the C═C bond in α,β-unsaturated carbonyl compounds, including natural product precursors with bulky substituents in the β position and substrates possessing an array of additional functional groups. It also catalyzes the hydrogenation of many isolated double bonds. Mechanistic studies reveal that no radical intermediates are involved, and the catalyst appears to be homogeneous, thereby affording important complementarity to existing protocols for similar hydrogenation processes.

Copper-Catalyzed Trifluoromethylation of Alkyl Bromides

Copper oxidative addition into organohalides is a challenging two-electron process. In contrast, formal oxidative addition of copper to C sp2 carbon-bromine bonds can be accomplished by employing latent silyl radicals under photoredox conditions. This novel paradigm for copper oxidative addition has now been applied to a Cu-catalyzed cross-coupling of C sp3-bromides. Specifically, a copper/photoredox dual catalytic system for the coupling of alkyl bromides with trifluoromethyl groups is presented. This operationally simple and robust protocol successfully converts a variety of alkyl, allyl, benzyl, and heterobenzyl bromides into the corresponding alkyl trifluoromethanes.

Synthesis of trifluoromethylated compounds from alcohols via alkoxydiphenylphosphines

The transformation of hydroxyl group in benzyl or allyl alcohols to trifluoromethyl was achieved via the reaction of the corresponding alkyloxydiphenylphosphine and CuCF3, generated in situ from methyl fluorosulfonyldifluoroacetate and CuI, under mild conditions. A plausible mechanism was proposed on the basis of experimental results.