121281-41-2 Usage
Uses
Diagnostic aid (brainimaging); radioactive agent.
General Description
Technetium(99mTc) bicisate is a neutral, lipophilic complex that crossesthe blood-brain barrier and is selectively retained in the brain.The kit used to prepare the product contains two vials.Vial “A” contains the ligand, tin, and other components thatmust be protected from light, whereas vial “B” contains abuffer solution. The radiopharmaceutical is prepared byadding sodium pertechnetate (99mTc) to the shielded “B” vialcontaining the buffer. The vial A containing lyophilized bicisate,EDTA, mannitol, and stannous chloride is reconstitutedwith 3 mL of normal saline (0.9% NaCl). Within 30seconds, 1 mL of the saline solution from vial A is transferredto vial B and allowed to incubate at room temperaturefor 30 minutes. The tagged product must be used within 6hours of preparation. The structure of the technetium complexis [N,N'-ethylene-di-L-cysteinato(3-)]oxo [99mTc]technetium(V) diethyl ester.After intravenous injection of 20 mCi (740 MBq) of Tc-99m bicisate, about 5% of the injected dose is localizedwithin the brain cells 5 minutes after injection. Ester hydrolysistraps the radiotracer within the brain. This radiotraceris indicated for the evaluation of stroke, but it is used offlabelto clinically evaluate various brain disorders, especiallybrain perfusion (“brain death”).
Check Digit Verification of cas no
The CAS Registry Mumber 121281-41-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,2,1,2,8 and 1 respectively; the second part has 2 digits, 4 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 121281-41:
(8*1)+(7*2)+(6*1)+(5*2)+(4*8)+(3*1)+(2*4)+(1*1)=82
82 % 10 = 2
So 121281-41-2 is a valid CAS Registry Number.