1213-78-1

Basic information

• Product Name: 2-Methyl-1-phenyl-indenol-⁽³⁾
• Synonyms: 2-Methyl-1-phenyl-indenol-⁽³⁾
• CAS NO: 1213-78-1
• Molecular Weight: 222.287
• Mol File: 1213-78-1.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 2-Methyl-1-phenyl-indenol-⁽³⁾(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Methyl-1-phenyl-indenol-⁽³⁾(1213-78-1)
• EPA Substance Registry System: 2-Methyl-1-phenyl-indenol-⁽³⁾(1213-78-1)

Safety Data

• Hazardous Substances Data: 1213-78-1(Hazardous Substances Data)

Upstream product

• 1238-46-6 <3-Hydroxy-2-methyl-3,3-diphenyl-propyliden>-cyclohexylamin 
• 673-32-5 1-Phenylprop-1-yne 
• 26260-02-6 2-iodobenzaldehyde 
• 40138-16-7 2-formylbenzene boronic acid 
• 119-61-9 benzophenone 

Relevant articles and documents

Synthesis of 1H-inden-1-ol derivatives via rhodium-catalyzed annulation of o-acylphenylboronic acids with alkynes

A rhodium-catalyzed annulation reaction of o-formyl-phenylboronic acid with alkynes occurred regioselectively at room temperature to give substituted 1H-inden-1-ol derivatives. o-Acetylphenylboronic acid also underwent the annulation reaction at 80°C to a

Cobalt-catalyzed regioselective carbocyclization reaction of o-iodophenyl ketones and aldehydes with alkynes, acrylates, and acrylonitrile: A facile route to indenols and indenes

An efficient cobalt-catalyzed carbocylization for the synthesis of indenols and indenes and a new method for reductive decyanation are described. 2-Iodophenyl ketones and aldehydes 1a-g undergo carbocyclization with various disubstituted alkynes 2a-k in the presence of Co(dppe)I2 and zinc powder in acetonitrile at 80 °C for 3 h to afford the corresponding indenol derivatives 3a-s and 4a-m in good to excellent yields. For some unsymmetrical alkynes, the carbocyclization was remarkably regioselective, affording a single regioisomer. The cobalt-catalyzed carbocyclization reaction was successfully extended to the synthesis of indene derivatives. Thus, the reaction of 2-iodophenyl ketones and aldehydes (1) with acrylates H2C=CHCO 2R (7a-d) and acrylonitrile H2C= CHCN (7e) proceeds smoothly in the presence of Co(dppe)Cl2/dppe and zinc powder in acetonitrile at 80 °C for 24 h to afford the corresponding indenes 8a-k and 9a-c in moderate to good yields. Interestingly, when 7e was employed for the carbocylization, reductive decyanation also occurred to give an indene derivative without the cyano functionality. A possible mechanism for this cobalt-catalyzed carbocyclization reaction is also proposed.