1213198-51-6 Usage
Description
N-BOC-3,5-DIFLUORO-D-TYROSINE is a chemical compound and an amino acid derivative, specifically a modified form of the naturally occurring tyrosine. It features two fluorine atoms at the 3rd and 5th positions, which may impart unique chemical and biological properties. The N-BOC (tert-butoxycarbonyl) group serves as a protective agent for the amino group, facilitating selective reactions at the carboxyl group. N-BOC-3,5-DIFLUORO-D-TYROSINE is significant in the fields of organic synthesis, peptide chemistry, and drug discovery research due to its distinctive structural attributes and potential for creating novel materials or bioactive substances.
Uses
Used in Organic Synthesis:
N-BOC-3,5-DIFLUORO-D-TYROSINE is used as a building block in organic synthesis for the creation of complex organic molecules. Its unique fluorinated structure can influence the reactivity and selectivity of the molecules it is incorporated into, making it a valuable component in the synthesis of pharmaceuticals and other specialty chemicals.
Used in Peptide Chemistry:
In peptide chemistry, N-BOC-3,5-DIFLUORO-D-TYROSINE is utilized as a non-natural amino acid for the synthesis of modified peptides. The protective N-BOC group allows for the selective incorporation of this amino acid into peptide sequences, which can be crucial for the development of new peptide-based drugs or for studying the effects of amino acid modifications on peptide properties.
Used in Drug Discovery Research:
N-BOC-3,5-DIFLUORO-D-TYROSINE is employed as a key component in drug discovery research. Its incorporation into drug candidates can lead to the development of new pharmaceuticals with improved pharmacokinetic and pharmacodynamic profiles. The presence of fluorine atoms can enhance the lipophilicity, metabolic stability, and binding affinity of drug molecules, making this compound a promising starting point for the design of innovative therapeutic agents.
Used in the Development of New Materials:
Due to its unique structure, N-BOC-3,5-DIFLUORO-D-TYROSINE can be used in the development of new materials with specific properties. The fluorine substituents may confer properties such as increased stability or altered reactivity, which can be harnessed in the creation of advanced materials for various applications, including sensors, catalysts, or coatings.
Used in Bioactive Compound Research:
N-BOC-3,5-DIFLUORO-D-TYROSINE is also used in the research of bioactive compounds. Its unique structure may lead to the discovery of new bioactive molecules with potential applications in medicine, agriculture, or environmental science. N-BOC-3,5-DIFLUORO-D-TYROSINE's ability to be selectively modified and incorporated into larger molecules makes it a versatile tool for exploring the effects of structural changes on biological activity.
Check Digit Verification of cas no
The CAS Registry Mumber 1213198-51-6 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,1,3,1,9 and 8 respectively; the second part has 2 digits, 5 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 1213198-51:
(9*1)+(8*2)+(7*1)+(6*3)+(5*1)+(4*9)+(3*8)+(2*5)+(1*1)=126
126 % 10 = 6
So 1213198-51-6 is a valid CAS Registry Number.
1213198-51-6Relevant articles and documents
Tertiary-butoxycarbonyl (Boc) – A strategic group for N-protection/deprotection in the synthesis of various natural/unnatural N-unprotected aminoacid cyanomethyl esters
Karmakar, Ananta,Basha, Mushkin,Venkatesh Babu,Botlagunta, Murali,Malik, Noormohamed Abdul,Rampulla, Richard,Mathur, Arvind,Gupta, Arun Kumar
supporting information, p. 4267 - 4271 (2018/11/03)
A number of cyanomethyl esters of natural/unnatural aminoacids with un-protected amino functionality were synthesized because of their synthetic and medicinal importance. Critical N-Boc deprotection methods in the presence of labile (hydrolytic sensitivity) cyanomethyl functionality were screened thoroughly and it was found that readily available 4M HCl in 1,4-dioxane solution (2–4 equiv); acetonitrile, 0 °C, 2–4 h was a suitable condition. This condition was generalized and successfully applied to a variety of alkyl, alkynyl, aryl, heteroaryl, benzyl, azido, spiro amino acid cyanomethylesters irrespective of the nature of the amine (primary or secondary) and the distance between the amine and ester group to achieve final deprotected amino esters with high yield, and purity compared to other commonly known N-protecting groups (Cbz, Fmoc, Ac, Bn, Bz etc.). It was also demonstrated that N-Boc protected aminoacid cyanomethylesters are stable enough to carry out further functionalization compared to N-unprotected counterparts.
