1213236-07-7Relevant academic research and scientific papers
Free radical scavenging activity of novel thiazolidine-2,4-dione derivatives
Berczynski, Pawel,Kruk, Irena,Piechowska, Teresa,Ceylan-Unlusoy, Meltem,Bozdag-Duendar, Oya,Aboul-Enein, Hassan Y.
, p. 900 - 904 (2014/01/06)
Free radical activity towards superoxide anion radical (O2?), hydroxyl radical (HO?) and 2,2-diphenyl-1-picrylhydrazyl (DPPH?) of a series of novel thiazolidine-2,4-dione derivatives (TSs) was examined using chemiluminescence, electron paramagnetic resonance (EPR) and EPR spin trapping techniques. 5,5-Dimethyl-1-pyrroline-N-oxide (DMPO) was applied as the spin trap. Superoxide radical was produced in the potassium superoxide/18-crown-6 ether dissolved in dimethyl sulfoxide. Hydroxyl radical was generated in the Fenton reaction (Fe(II) + H2O2. It was found that TSs showed a slight scavenging effect (15-38% reduction at 2.5 mmol/L concentration) of the DPPH radical and a high scavenging effect of O2? (41-88%). The tested compounds showed inhibition of HO ? -dependent DMPO-OH spin adduct formation (the amplitude of EPR signal decrease ranged from 20 to 76% at 2.5 mmol/L concentration. Our findings present new group compounds of relatively high reactivity towards free radicals. Copyright 2012 John Wiley & Sons, Ltd. Copyright
