1213236-65-7Relevant academic research and scientific papers
Designing dendrimers for ocular drug delivery
Spataro, Gregory,Malecaze, Francois,Turrin, Cedric-Olivier,Soler, Vincent,Duhayon, Carine,Elena, Pierre-Paul,Majoral, Jean-Pierre,Caminade, Anne-Marie
experimental part, p. 326 - 334 (2010/04/04)
New series of phosphorus-containing dendrimers, having one quaternary ammonium salt as core and carboxylic acid terminal groups have been synthesized from generation 0 (3 carboxylic acid terminal groups) to generation 2 (12 carboxylic acid terminal groups). These dendrimers react with the neutral form of carteolol (an ocular anti-hypertensive drug used to treat glaucoma) to afford ion pair (saline) species. The solubility in water of these charged dendrimers depends on the generation considered: generation 0 (3 carteolol) is well soluble, whereas generation 1 (6 carteolol) and generation 2 (12 carteolol) are poorly soluble. These dendrimers have been tested in vivo, as vehicle for ocular drug delivery of carteolol to rabbits.
