1213237-52-5Relevant academic research and scientific papers
6-Substituted 2-(N-trifluoroacetylamino)imidazopyridines induce cell cycle arrest and apoptosis in SK-LU-1 human cancer cell line
Martínez-Urbina, Miguel Angel,Zentella, Alejandro,Vilchis-Reyes, Miguel Angel,Guzmán, ángel,Vargas, Omar,Ramírez Apan, María Teresa,Ventura Gallegos, José Luis,Díaz, Eduardo
experimental part, p. 1211 - 1219 (2010/05/02)
A series of 6-substituted 2-(N-trifluoroacetylamino)imidazopyridines have been synthesized and their bioactivities were evaluated. Compounds 6a, 6c, and 11a were the most active compounds with modest cytotoxic activity against six human cancer cell lines U251 (glioma), PC-3 (prostate), K-562 (leukemia), HCT-15 (colon), MCF7 (breast) and SK-LU-1 (lung). The cell cycle analysis showed that compounds 6a, 6c, and 11a induce a G2/M phase cell cycle arrest on SK-LU-1 cell line where inhibition of CDK-1 and CDK-2 may be implicated.
