121324-22-9Relevant academic research and scientific papers
Acylated oleanane-type triterpene saponins from the flowers of Bellis perennis show anti-proliferative activities against human digestive tract carcinoma cell lines
Ninomiya, Kiyofumi,Motai, Chiaki,Nishida, Eriko,Kitagawa, Niichiro,Yoshihara, Kazuya,Hayakawa, Takao,Muraoka, Osamu,Li, Xuezheng,Nakamura, Seikou,Yoshikawa, Masayuki,Matsuda, Hisashi,Morikawa, Toshio
, p. 435 - 451 (2016)
Seven oleanane-type triterpene saponin bisdesmosides, perennisaponins N–T (1–7), were newly isolated from a methanol extract of daisy, the flowers of Bellis perennis L. (Asteraceae). The structures were determined based on chemical and physicochemical data and confirmed using previously isolated related compounds as references. The isolates, including 13 previously reported perennisaponins A–M (8–20), exhibited anti-proliferative activities against human digestive tract carcinoma HSC-2, HSC-4, and MKN-45 cells. Among them, perennisaponin O (2, IC50?=?11.2, 14.3, and 6.9?μM, respectively) showed relatively strong activities. The mechanism of action of 2 against HSC-2 was found to involve apoptotic cell death.
Medicinal flowers. Part 29. Acylated oleanane-type triterpene bisdesmosides: Perennisaponins G, H, I, J, K, L, and M with pancreatic lipase inhibitory activity from the flowers of Bellis perennis
Morikawa, Toshio,Li, Xuezheng,Nishida, Eriko,Nakamura, Seikou,Ninomiya, Kiyofumi,Matsuda, Hisashi,Oda, Yoshimi,Muraoka, Osamu,Yoshikawa, Masayuki
, p. 573 - 586 (2010)
The MeOH extract from the flowers of Bellis perennis was found to show pancreatic-lipase inhibitory activity (IC50 455 μg/ml). From the extract, seven new triterpene saponins named perennisaponins G (1; IC 50 163 μm), H (2; 137 μm),
