1213253-03-2Relevant academic research and scientific papers
Novel and facil synthesis and evaluation of antitumor activities of 6,7-bisaryl-1-(β-D-ribofuranosyl)pteridine-2,4(1H,3H)-diones
Kandahary, Rafiya Khan,Hossion, Abugafar M.L.,Ashida, Noriyuki,Nagamatsu, Tomohisa
experimental part, p. 557 - 577 (2010/04/27)
Novel 6,7-bisaryl-1-(β-D-ribofuranosyl)pteridine-2,4(1H,3H)-dione derivatives were synthesized by condensation of 5,6-diamino-2′,3′-O-isopropylideneuridine, which was derived from uridine, with an appropriate α,β-diketone, followed by acidic hydrolysis allowing removal of the isopropylidene group of the sugar moiety as a protecting group. Moreover, several N-3 alkyl derivatives of the 6,7-bisaryl-1-(β-D-ribofuranosyl)pteridine-2,4(1H,3H)-diones were obtained by alkylation of the 6,7-bisaryl-1-(2′,3′-O-isopropylidene-β-D-ribofuranosyl)pteridine-2,4(1H,3H)-diones with alkyl halides and by their acidic hydrolysis for deprotection. The antitumor activities of all synthesized compounds against CCRF-HSB-2 and KB cell lines were also investigated in vitro and some of the compounds showed prospective antitumor activities.
