1213264-42-6

Basic information

• Product Name: C₆₀H₆₈N₂O₂₂S₂
• CAS NO: 1213264-42-6
• Molecular Weight: 1233.33
• Mol File: 1213264-42-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₆₀H₆₈N₂O₂₂S₂(CAS DataBase Reference)
• NIST Chemistry Reference: C₆₀H₆₈N₂O₂₂S₂(1213264-42-6)
• EPA Substance Registry System: C₆₀H₆₈N₂O₂₂S₂(1213264-42-6)

Safety Data

• Hazardous Substances Data: 1213264-42-6(Hazardous Substances Data)

Upstream product

• 10389-65-8 di-t-butoxycarbonyl-L-cystine 
• 518-28-5 podofilox 

Downstream Products

• 1213264-36-8 dipodophyllotoxin-4-yl 3,3'-bisthio-2-amino propanoate 

Relevant articles and documents

Synthesis and biological evaluation of novel thiocolchicine-podophyllotoxin conjugates

The synthesis and biological evaluation of 9 dimeric compounds obtained by condensation of thiocolchicine and/or podophyllotoxin with 6 different dicarboxylic acids is described. In particular, tubulin assembly assay and immunofluorescence analysis results are reported. The biological data highlighted three compounds as being more active than the others, having a marked ability to inhibit the polymerization of tubulin in vitro and causing significant disruption to the microtubule network in vivo. The spacer unit was found to have a significant effect on biological activity, reinforcing the importance of the design of conjugate compounds to create new biologically active molecules in which the spacer could be useful to improve the solubility and to modulate the efficacy of well known anticancer drugs.