1213264-98-2Relevant academic research and scientific papers
Syntheses and biological evaluation of irciniastatin A and the C1-C2 alkyne analogue
Watanabe, Tsubasa,Imaizumi, Takamichi,Chinen, Takumi,Nagumo, Yoko,Shibuya, Masatoshi,Usui, Takeo,Kanoh, Naoki,Iwabuchi, Yoshiharu
supporting information; experimental part, p. 1040 - 1043 (2010/06/15)
Chemical equation presented Syntheses of both natural (+)- and unnatural (-)-irciniastatin A (aka psymberin) as well as a C1-C2 alkyne analogue of (+)-irciniastatin A have been achieved. The key features of the syntheses include a highly regioselective epoxide-opening reaction and a late-stage assembly of C1-C6, C8-C16, and C17-C25 fragments. (+)-Alkymberin retained a high level of cytotoxicity, whereas (-)-irciniastatin A showed almost no activity. These results suggest that (+)-alkymberin could be a useful enantio-differential probe for mode-of-action study.
