121348-15-0

Basic information

• Product Name: 5-ACETYL-2-CHLORO-6-METHYLNICOTINONITRILE
• Synonyms: 5-ACETYL-2-CHLORO-6-METHYLNICOTINONITRILE
• CAS NO: 121348-15-0
• Molecular Formula: C₉H₇ClN₂O
• Molecular Weight: 194.62
• Mol File: 121348-15-0.mol
• Article Data: 3

Chemical Properties

• Melting Point: 81-83°
• Appearance: /
• CAS DataBase Reference: 5-ACETYL-2-CHLORO-6-METHYLNICOTINONITRILE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-ACETYL-2-CHLORO-6-METHYLNICOTINONITRILE(121348-15-0)
• EPA Substance Registry System: 5-ACETYL-2-CHLORO-6-METHYLNICOTINONITRILE(121348-15-0)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 121348-15-0(Hazardous Substances Data)

Upstream product

• 52600-53-0 5-acetyl-1,2-dihydro-6-methyl-2-oxonicotinonitrile 

Downstream Products

• 121348-09-2 3-Acetyl-5-cyano-2-methyl-6-morpholino-pyridine 
• 860609-51-4 methyl 5-acetyl-3-amino-6-methylthieno[2,3-b]pyridine-2-carboxylate 

Relevant articles and documents

Discovery and optimization of thienopyridine derivatives as novel urea transporter inhibitors

Urea transporters (UTs) play an important role in the urine concentrating mechanism and are recognized as novel targets for developing small molecule inhibitors with salt-sparing diuretic activity. Thienoquinoline derivatives, a class of novel UT-B inhibitors identified by our group, play a significant diuresis in animal model. However, the poor solubility and low bioavailability limited its further development. To overcome these shortcomings, the structure modification of thienoquinoline was carried out in this study, which led to the discovery of novel thienopyridine derivatives as specific urea transporter inhibitors. Further optimization obtained the promising preclinical candidate 8n with not only excellent inhibition effect on urea transporters and diuretic activity on rat model, but also suitable water solubility and Log P value.

Substituted pyridylethanolamine livestock production promoters

For promoting livestock production, the novel substituted pyridylethanolamines of the formula STR1 in which R1 represents CN, --COOR8 or --CONR9 R10, R2 represents optionally substituted alkyl, R3 represents hydrogen, alkyl or alkenyl, R4 represents hydrogen or optionally substituted alkyl or alkenyl, or R3 and R4 represent, together with the nitrogen atom to which they are bonded, an optionally substituted heterocyclic radical, R5 represents OH, acyloxy or alkoxy, R6 represents hydrogen or alkyl, R7 represents hydrogen, alkyl, cycloalkyl, substituted alkyl, optionally substituted aralkyl, aryl or heterocyclyl, R6 and R7 can, together with the nitrogen atom to which they are bonded, represent an optionally substituted heterocyclic radical, R8 represents alkyl, and R9 and R10, independently of one another, represent hydrogen, alkyl or alkenyl or, together with the nitrogen atom to which they are bonded, represent an optionally substituted heterocyclic radical, or a physiologically tolerated salt or N-oxide thereof. Some intermediates are also new.