1213648-97-5

Basic information

• Product Name: METHYL (3R)-3-AMINO-3-(4-METHYLPHENYL)PROPANOATE
• Synonyms: METHYL (3R)-3-AMINO-3-(4-METHYLPHENYL)PROPANOATE;(R)-methyl 3-amino-3-(p-tolyl)propanoate
• CAS NO: 1213648-97-5
• Molecular Formula: C₁₁H₁₅NO₂
• Molecular Weight: 193.24
• Mol File: 1213648-97-5.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• CAS DataBase Reference: METHYL (3R)-3-AMINO-3-(4-METHYLPHENYL)PROPANOATE(CAS DataBase Reference)
• NIST Chemistry Reference: METHYL (3R)-3-AMINO-3-(4-METHYLPHENYL)PROPANOATE(1213648-97-5)
• EPA Substance Registry System: METHYL (3R)-3-AMINO-3-(4-METHYLPHENYL)PROPANOATE(1213648-97-5)

Safety Data

• Hazardous Substances Data: 1213648-97-5(Hazardous Substances Data)

Upstream product

• 1103893-77-1 (Z)-methyl 3-(4-methoxyphenylamino)-3-p-tolylacrylate 
• 198959-38-5 3-amino-3-(4-methylphenyl)propionic acid methyl ester 

Relevant articles and documents

Synthesis of: N -aryl β-amino acid derivatives via Cu(ii)-catalyzed asymmetric 1,4-reduction in air

In the presence of the inexpensive and stable stoichiometric reductant polymethylhydrosiloxane (PMHS) as well as certain amounts of appropriate alcohol and base additives, the non-precious metal copper-catalyzed asymmetric 1,4-hydrosilylation of β-aryl or β-alkyl-substituted N-aryl β-enamino esters was well realized to afford a diverse range of N-aryl β-amino acid esters in high yields and excellent enantioselectivities (26 examples, 90-98% ee). This approach tolerated the handling of both catalyst and reactants in air without special precautions. The chiral products obtained have been successfully converted to the corresponding enantiomerically enriched β-lactam and unprotected β-amino acid ester, which highlighted the synthetic utility of the developed catalytic procedure.