1213669-91-0Relevant academic research and scientific papers
POLYMORPHS OF 7-(TERT-BUTYL-D9)-3-(2,5-DIFLUOROPHENYL)-6-((1-METHYL-1H-1,2,4-TRIAZOL-5-YL)METHOXY)-[1,2,4]TRIAZOLOL[4,3B]PYRIDAZINE
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Paragraph 105 - 107, (2013/12/03)
The present invention provides individual crystalline polymorphs of 7-(tert-Butyl-d9)-3-(2,5-difluorophenyl)-6-((1-methyl-1H-1,2,4- triazol-5-yl)methoxy)-[1,2,4]triazolo[4,3-b]pyridazine designated Form 1, Form 3 and Form 4. Each polymorph disclosed herein is characterized according to one or more of (a) powder X-ray diffraction data ( XRPD ); (b) differential scanning calorimetry ( DSC ); and (e) thermogravimetric analysis (TGA).
FORM 5 POLYMORPH OF 7-(TERT-BUTYL-D9)-3-(2,5-DIFLUOROPHENYL)-6((1-METHYL-1H-1,2,4-TRIAZOL-5-YL)METHOXY)-[1,2,4]TRIAZOLO[4,3-B]PYRIDAZINE
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Paragraph 57; 58, (2013/12/03)
The present invention provides individual crystalline polymorphs of 7-(tert-Butyl- d9)-3-(2,5-difluorophenyl)-6-((1-methyl-1H-1,2,4-triazol-5-yl)methoxy)- [1,2,4]triazolo[4,3-b]pyridazine designated Form 5. The Form 5 polymorph disclosed herein is characterized according to one or more of (a) powder X-ray diffraction data ( XRPD ); (b) differential scanning calorimetry ( DSC ); (c) FT-Raman spectroscopy; (d) FT-IR spectroscopy; and (e) thermogravimetric analysis (TGA).
SUBSTITUTED TRIAZOLO-PYRIDAZINE DERIVATIVES
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Page/Page column 16, (2010/04/06)
This invention relates to novel substituted triazolo-pyridazines, their derivatives, and pharmaceutically acceptable salts thereof. This invention also provides compositions comprising a compound of this invention and the use of such compositions in methods of treating diseases and conditions that are beneficially treated by administering an α1 -GABA-A receptor antagonist and/or a α2, α3 and α5 GABA-A receptor agonist.
