1213707-22-2Relevant academic research and scientific papers
Exploring the effect of 2,3,4-trimethoxy-phenyl moiety as a component of indolephenstatins
álvarez, Concepción,álvarez, Raquel,Corchete, Purificación,Pérez-Melero, Concepción,Peláez, Rafael,Medarde, Manuel
experimental part, p. 588 - 597 (2010/04/26)
A new family of phenstatin analogues has been synthesized and assayed. This family simultaneously incorporates modifications of the A-ring (replacement of the 3,4,5-trimethoxyphenyl by the 2,3,4-trimethoxyphenyl arrangement), B-ring (N-alkyl-5-indolyl) and conversion of the Oxygen keto group into a substituted nitrogen (oximes, hydrazones, and their acetylderivatives). The conjunction of all this changes greatly diminishes the antimitotic and antiproliferative activities, but the maintenance of the keto bridge produces a potent analogue with the unusual 2,3,4-trimethoxyphenyl moiety.
