1213779-34-0Relevant academic research and scientific papers
Stereoselective acetate aldol reactions of α-silyloxy ketones
Lorente, Adriana,Pellicena, Miquel,Romea, Pedro,Urpí, Fèlix
, p. 1023 - 1035 (2015)
TiCl4-mediated aldol reactions of chiral methyl α-silyloxy ketones with a variety of aldehydes provide the corresponding 1,4-syn aldol adducts with moderate to high stereocontrol. This transformation represents a new approach to substrate-controlled acetate aldol reactions and complements the 1,4-anti asymmetric induction produced by the related α-benzyloxy ketones. This new approach could be useful in the design of more efficient syntheses of natural products.
1,4-syn-Asymmetric induction in the titanium-mediated aldol reactions of chiral methyl α-silyloxy ketones
Lorente, Adriana,Pellicena, Miquel,Romea, Pedro,Urpí, Fèlix
experimental part, p. 942 - 945 (2010/04/29)
Good levels of 1,4-syn asymmetric induction are obtained in the TiCl4-mediated aldol reaction of methyl α-silyloxy ketones with achiral aldehydes. Such methodology represents a new approach to the substrate-controlled acetate aldol reaction, which can be useful to design more efficient syntheses of natural products.
