121378-49-2Relevant academic research and scientific papers
Asymetric Electrophilic α-Amidoalkylation 4: Generation and Trapping Reactions of Chiral N-Acylpyrrolidiniumions
Wanner, Klaus Th.,Hoefner, Georg
, p. 99 - 103 (2007/10/02)
The pyrrole derivatives 1, 6, and 10 react in the presence of TiCl4 with the silyl enol ether 3 to form α-substituted pyrrolidine amides stereoselectively. 6 and 10 (after HCl-addition =>11) react even at -78 deg C, the reaction of 10 exceeds that of 6 in yield and stereoselctivity.
