1213846-75-3 Usage
General Description
"(R)-Cyclopropyl(2-fluorophenyl)MethanaMine hydrochloride is a chemical compound with a complex structure. It contains a cyclopropyl group, which involves a ring of three carbon atoms, and a 2-fluorophenyl group, which is a phenyl group wherein one hydrogen atom is replaced by a fluorine atom. The methanamine part of the compound refers to the simplest type of organic amine, which has a single carbon atom. The compound is in its hydrochloride form, meaning it's combined with hydrochloric acid. It's important to note that the "(R)-" at the beginning refers to the compound's stereochemistry, indicating the spatial arrangement of its atoms and groups. Details about its specific uses or properties are not general knowledge and would depend on the context or the specific field in which it is utilized.
Check Digit Verification of cas no
The CAS Registry Mumber 1213846-75-3 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,1,3,8,4 and 6 respectively; the second part has 2 digits, 7 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 1213846-75:
(9*1)+(8*2)+(7*1)+(6*3)+(5*8)+(4*4)+(3*6)+(2*7)+(1*5)=143
143 % 10 = 3
So 1213846-75-3 is a valid CAS Registry Number.
1213846-75-3Relevant articles and documents
New quinoline NK3 receptor antagonists with CNS activity
Smith, Paul W.,Wyman, Paul A.,Lovell, Peter,Goodacre, Caroline,Serafinowska, Halina T.,Vong, Antonio,Harrington, Frank,Flynn, Sean,Bradley, Daniel M.,Porter, Rod,Coggon, Sara,Murkitt, Graham,Searle, Kirsten,Thomas, David R.,Watson, Jeannette M.,Martin, William,Wu, Zining,Dawson, Lee A.
scheme or table, p. 837 - 840 (2009/09/06)
Lead optimisation starting from the previously reported selective quinoline NK3 receptor antagonists talnetant 2 (SB-223412) and 3 (SB-222200) led to the identification of 3-aminoquinoline NK3 antagonist 10 (GSK172981) with excellent CNS penetration. Investigation of a structurally related series of sulfonamides with reduced lipophilicity led to the discovery of 20 (GSK256471). Both 10 and 20 are high affinity, potent NK3 receptor antagonists which despite having different degrees of CNS penetration produced excellent NK3 receptor occupancy in an ex vivo binding study in gerbil cortex.