121405-33-2Relevant academic research and scientific papers
Synthesis of 7H-tetrazolo[1,5-c]pyrrolo[3,2-e]pyrimidines and their reductive ring cleavage to 4-aminopyrrolo[2,3-d]pyrimidines
Dave, Chaitanya G.,Shah, Rina D.
, p. 1295 - 1300 (2007/10/03)
Some new 7,9-disubstituted 7H-1,2,3,4-tetrazolo[1,5-c]pyrrolo[3,2- e]pyrimidines 5 have been synthesized either by diazotization of 4-hydrazino- 5,7-disubstituted-7H-pyrrolo[2,3-d]pyrimidines 4 obtained by hydrazinolysis of 4-chloro-5,7-disubstituted-7H-pyrrolo[2,3-d]pyrimidines 3 or via a substitution reaction between 3 and sodium azide. 5,7-Disubstituted-7H- pyrrolo[2,3-d]pyrimidin-4(3H)-ones 2 were obtained by cyclocondensation of 2- amino-3-cyano-1,4-disubstituted pyrroles 1 with formic acid which on chlorination using phosphorus oxychloride afforded 3. A novel route for the synthesis of 4-amino-5,7-disubstituted-7H-pyrrolo[2,3-d]pyrimidines 6 by the reductive ring cleavage of 5 has been reported.
Synthesis and Biological Activity of Pyrrolopyrimidines
Dave, Chaitanya G.,Shah, P. R.,Upadhyaya, S. P.,Gandhi, T. P.,Patel, R. B.
, p. 778 - 780 (2007/10/02)
2-Amino-3-cyanopyrroles (I) on reaction with formamide and carbon disulphide in pyridine give 4-amino-5,6,7-trisubstituted-7H-pyrrolopyrimidines (II) and 5,6,7-trisubstitutedpyrrolopyrimidine-2,4(1H,3H)-dithiones (III), respectively. 2,4-Bis(methylmercapto)-5,6,7-trisubstitutedpyrrolopyrimidines (IV) have been prepared by reacting III with dimethyl sulphate in basic medium.Structures of the synthesized compounds have been established by elemental analyses and spectral data.Some of them have been screened for their antibacterial, analgesic, antiinflammatory, antihistaminic, anticholinergic, anticonvulsant and antihypertensive activities.
