121405-37-6

Basic information

• Product Name: 1H-Pyrrolo[2,3-d]pyrimidin-4-amine, 5-(4-methoxyphenyl)-
• CAS NO: 121405-37-6
• Molecular Formula: C13H12N4O
• Molecular Weight: 240.264
• Mol File: 121405-37-6.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 1H-Pyrrolo[2,3-d]pyrimidin-4-amine, 5-(4-methoxyphenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Pyrrolo[2,3-d]pyrimidin-4-amine, 5-(4-methoxyphenyl)-(121405-37-6)
• EPA Substance Registry System: 1H-Pyrrolo[2,3-d]pyrimidin-4-amine, 5-(4-methoxyphenyl)-(121405-37-6)

Safety Data

• Hazardous Substances Data: 121405-37-6(Hazardous Substances Data)

Upstream product

• 120450-06-8 2-amino-4-(4-methoxyphenyl)-1H-pyrrole-3-cyanide 
• 77287-34-4 formamide 
• 344427-70-9 N-[3-cyano-4-(4-methoxy-phenyl)-1H-pyrrol-2-yl]-formamidine 
• 6595-28-4 2-azido-1-(4-methoxyphenyl)ethan-1-one 
• 3755-89-3 N-(2-(4-methoxyphenyl)-2-oxoethyl)acetamide 
• 40513-43-7 2-amino-1-(4-methoxy-phenyl)-ethanone 
• 2632-13-5 2-Bromo-4'-methoxyacetophenone 

Relevant articles and documents

7-alkyl- and 7-cycloalkyl-5-aryl-pyrrolo[2,3-d]pyrimidines - Potent inhibitors of the tyrosine kinase c-Src

7-Substituted-5-aryl-pyrrolo[2,3-d]pyrimidines have been prepared starting from α-bromoacetophenones. These compounds represent a novel class of potent inhibitors of the tyrosine kinase pp60c-Src with good specificity towards other tyrosine kinases (EGF-R, v-Abl).

Synthesis and Biological Activity of Pyrrolopyrimidines

2-Amino-3-cyanopyrroles (I) on reaction with formamide and carbon disulphide in pyridine give 4-amino-5,6,7-trisubstituted-7H-pyrrolopyrimidines (II) and 5,6,7-trisubstitutedpyrrolopyrimidine-2,4(1H,3H)-dithiones (III), respectively. 2,4-Bis(methylmercapto)-5,6,7-trisubstitutedpyrrolopyrimidines (IV) have been prepared by reacting III with dimethyl sulphate in basic medium.Structures of the synthesized compounds have been established by elemental analyses and spectral data.Some of them have been screened for their antibacterial, analgesic, antiinflammatory, antihistaminic, anticholinergic, anticonvulsant and antihypertensive activities.