121406-90-4

Upstream product

• 58479-61-1 tert-butylchlorodiphenylsilane 
• 60-24-2 2-hydroxyethanethiol 

Downstream Products

• 121407-28-1 3-[2-(tert-Butyl-diphenyl-silanyloxy)-ethanesulfonyl]-propionic acid ethyl ester 
• 121407-20-3 (5R,6S)-6-[(R)-1-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-3-[2-(tert-butyl-diphenyl-silanyloxy)-ethanesulfonylmethyl]-7-oxo-4-thia-1-aza-bicyclo[3.2.0]hept-2-ene-2-carboxylic acid allyl ester 
• 1020296-20-1 C₃₇H₄₁NO₄SSi 
• 1282036-34-3 C₁₈H₁₈N₂O₄ 
• 1227613-68-4 C₂₈H₃₃NO₄SSi 
• 1245082-83-0 C₂₅H₂₇NO₅SSi 
• 1245082-85-2 C₂₈H₄₂N₂O₄SSi 
• 1602768-18-2 4-(2-(tert-butyldiphenylsilyloxy)ethylthio)-7-nitrobenzo[c][1,2,5]oxadiazole 

Relevant academic research and scientific papers

PYRROLOBENZODIAZEPINE PRODRUGS AND ANTIBODY CONJUGATES THEREOF

The invention relates generally to pyrrolobenzodiazepine monomer and dimer prodrugs having a glutathione-activated disulfide prodrug moiety, a DT-diaphorase-activated quinone prodrug moiety or a reactive oxygen species-activated aryl boronic acid or aryl boronic ester prodrug moiety. The invention further relates to pyrrolobenzodiazepine prodrug dimer-antibody conjugates.

A reduction sensitive cascade biodegradable linear polymer

Cascade degradable linear polymers offer the potential for a high degree of control over the degradation process. They comprise a backbone that is stable in the presence of an end cap, but upon removal of the end cap a cascade of intramolecular reactions

Development of a new nonpeptidic self-immolative spacer. application to the design of protease sensing fluorogenic probes

The design and synthesis of novel self-immolative spacer systems aiming at the release of phenol-containing compounds are described. The newly designed traceless linkers proved to be conveniently stable under physiological conditions and operate through spontaneous decomposition of an hemithioaminal intermediate under neutral aqueous conditions. Their utility was then illustrated by the preparation of original fluorogenic substrates of penicillin amidase whose strong fluorescence is unveiled through enzyme-initiated domino reactions.