121407-29-2Relevant academic research and scientific papers
Asymmetric Syntheses of Chiral Propane-1,3-diols Starting from Malonic Acid
Ihara, Masataka,Takahashi, Masanobu,Taniguchi, Nobuaki,Yasui, Ken,Fukumoto, Keiichiro,Kametani, Tetsuji
, p. 897 - 903 (2007/10/02)
Syntheses of chiral intermediates having one tertiary asymmetric centre were carried out via chiral half-esters of monoalkylmalonic acids.The menthyl half-ester of ethylmalonic acid afforded a single diastereoisomer through crystallisation-induced asymmetric transformation (second-order asymmertic transformation).Furthermore enantioselective preparation of unsymmertical propane-1,3-diol derivatives was achieved by the use of 8-phenylmenthyl half-esters.
Highly Stereocontrolled Synthesis of the Key Intermediate of 1β-Methylcarbapenem Antibiotic via Intramolecular Nitrone 1,3-Dipolar Cycloaddition
Ihara, Masataka,Takahashi, Masanobu,Fukumoto, Keiichiro,Kametani, Tetsuji
, p. 9 - 10 (2007/10/02)
The key synthetic intermediate of 1β-methylcarbapenem antibiotic, (-)-(3S,4R)-3--4-azetidin-2-one (2), was synthesized from (R)-methyl 3-hydroxy-2-methylpropionate with high stereoselectivity vi
