121409-72-1Relevant academic research and scientific papers
Lewis Acid-Mediated Decarboxylative Allylation of Enol Carbonates
Dokai, Yoichi,Nishizawa, Takuma,Saito, Kodai,Yamada, Tohru
, (2021)
A homoallylic ketone can be transformed and functionalized by various synthetic reactions, and thus, is regarded as one of the representative building blocks in organic chemistry. An additional route to access homoallylic ketones, namely, a Lewis acid-mediated decarboxylative allylation of cyclic enol carbonates, prepared by fixation of carbon dioxide onto propargyl alcohols, was developed in this work. The treatment of a cyclic enol carbonate with a Lewis acid in the presence of an allylsilane resulted in the formation of a homoallylic ketone. It was found that the title reaction proceeded well by the combined use of zirconium tetrachloride with allyltrimethylsilane. The allylation occurred with high regioselectivity and the corresponding homoallylic ketones were obtained in good-to-high yields. A reaction mechanism involving the decarboxylative formation of an oxyallyl cation equivalent is proposed.
Diaryl-2-(5H)-furanones as Cox-2 inhibitors
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, (2008/06/13)
The invention encompasses the novel compound of Formula (I) as well as a method of treating cyclooxygenase-2 mediated diseases comprising administration to a patient in need of such treatment of a non-toxic therapeutically effective amount of a compound of Formula (I). The invention also encompasses certain pharmaceutical compositions for treatment of cyclooxygenase-2 mediated diseases comprising compounds of Formula (I).
An Efficient Synthesis of 4,4-Disubstituted 5,6-Dihydro-3(4H)-pyridinone 1-Oxides by Thermal Cyclisation of Unsaturated 1,2-Hydroxyiminoketones
Bishop, Roger,Brooks, Peter R.,Hawkins, Stephen C.
, p. 997 - 999 (2007/10/02)
3,3-Disubstituted 1,2-hydroxyiminoketones 6 with the hydroxyimino group distal and δ,ε to an olefinic bond undergo thermal cyclisation to produce high yields of 4,4-disubstituted 5,6-dihydro-3(4H)-pyridinone 1-oxides 7.
