121412-57-5Relevant articles and documents
4-Amino-substituted 1,2-dihydroxynaphthalene derivatives useful in inhibiting 5-lipoxygenase activity in mammals
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, (2008/06/13)
Disclosed are compounds of the formula STR1 wherein R1 represents unsubstituted or lower alkyl-substituted C3 -C7 -cycloalkyl, unsubstituted or lower alkyl substituted C7 -or C8 -bicycloalkyl, unsubstituted or lower alkyl-substituted adamantyl, 4-piperidinyl or N-lower alkyl or aryl-lower alkyl-substituted piperidinyl, 1- or 2-indanyl, 1- or 2-tetrahydronaphthyl, 1- or 2-perhydroindanyl, 1- or 2-perhydronaphthyl; R2 represents hydrogen, lower alkyl, C3 -C7 -cycloalkyl, aryl-lower alkyl, C3 -C7 -cycloalkyl-lower alkyl, lower alkanoyl or aryl-lower alkanoyl; or R1 and R2 combined with the nitrogen to which they are attached represent pyrrolidino, piperidino, perhydroazepino, morpholino, thiomorpholino, tetrahydro- or perhydro-(isoquinolinyl or quinolinyl), dihydro- or perhydroindolyl, piperazino or N-lower alkyl-piperazino; R3 represents hydrogen, lower alkyl, halogen or lower alkoxy; pharmaceutically acceptable ester and ether derivatives thereof; and pharmaceutically acceptable acid-addition salts of any said basic compounds of formula I and derivatives thereof; as 5-lipoxygenase inhibitors.
