1214329-07-3

Usage

Uses

Used in Pharmaceutical Synthesis:
Methyl 5-bromo-6-methoxypicolinate is used as an intermediate for the synthesis of various pharmaceuticals, contributing to the development of new drugs and therapeutic agents.
Used in Agrochemical Production:
In the agrochemical industry, Methyl 5-bromo-6-methoxypicolinate is utilized as an intermediate, playing a role in the creation of compounds that can enhance crop protection and yield.
Used in Organic Synthesis:
Methyl 5-bromo-6-methoxypicolinate is used as a reagent for the formation of carbon-carbon and carbon-heteroatom bonds, facilitating complex organic synthesis processes.
Used in Research and Development:
As a building block, Methyl 5-bromo-6-methoxypicolinate is employed in the preparation of novel compounds for research purposes, aiding in the discovery and innovation of new chemical entities with potential applications in various fields.

Upstream product

• 1214334-70-9 5-bromo-6-methoxypyridine-2-carboxylic acid 
• 74-88-4 methyl iodide 
• 185017-72-5 3-bromo-2-chloro-6-methyl pyridine 
• 717843-47-5 3-bromo-2-methoxy-6-methylpyridine 
• 52200-48-3 3-bromo-2-chloropyridine 
• 1402004-06-1 methyl 5-bromo-6-methoxypyridine-2-carboximidoate 
• 1256823-65-0 5-bromo-6-chloropyridine-2-carbonitrile 
• 1373126-39-6 3-bromo-2-chloropyridine 1-oxide 

Downstream Products

• 1373126-40-9 ethyl 5-(5,5-dimethyl-1,3,2-dioxaborinan-2-yl)-6-methoxypyridine-2-carboxylate 
• 1402004-07-2 methyl 6-methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine-2-carboxylate 
• 1206775-52-1 5-bromo-6-methoxypyridine-2-carbaldehyde 

Relevant academic research and scientific papers

Synthesis and biological evaluation of novel series of 3-substituted 2-methoxy-6-(5-phenyl-[1,3,4]oxadiazol-2-yl)pyridine derivatives as antimicrobial agents

A series of novel 2-methoxy-3-phenyl-6-(5-phenyl-[1,3,4]oxadiazol-2-yl)pyridine (6a-h) have been synthesized from bromo methoxy picoline as starting material. Finally, oxadiazoles were coupled with various boronic acids using Suzuki coupling reactions to give the target compounds. The newly synthesized compounds were evaluated for their efficacy as antimicrobial agents against various Grampositive and Gram-negative strains of bacteria and fungal strains. Compounds 6g and 6h possessing fluoro groups at second and fourth positions of the aniline ring exhibited broad spectrum inhibition against all the strains tested. Moreover, other compounds also found to be potential fungal agents in comparison to the standard drugs.

SUBSTITUTED TETRAHYDROFURANS AS MODULATORS OF SODIUM CHANNELS

Compounds, and pharmaceutically acceptable salts thereof, useful as inhibitors of sodium channels are provided. Also provided are pharmaceutical compositions comprising the compounds or pharmaceutically acceptable salts and methods of using the compounds, pharmaceutically acceptable salts, and pharmaceutical compositions in the treatment of various disorders, including pain.

Synthesis and biological evaluation of 2-methoxy-n-phenyl-6-(5-phenyl-1, 3,4-oxadiazol-2-yl) pyridin-3-amine derivatives as antimicrobial agents

Background: A series of novel 2-methoxy-N-phenyl-6-(5-phenyl-1,3,4-oxadiazol-2- yl)pyridin-3-amine (6a-i) have been synthesized from bromo methoxy picolinicacid as starting material. Finally, oxadiazole was coupled with various anilines using buchwald coupling reactions to give the target compounds. The newly synthesized compounds were evaluated for their efficacy as antimicrobial agents against various Gram-positive and Gram-negative strains of bacteria and fungal strains. Compounds 6h and 6i possessing trifluoromethyl groups at second and fourth positions of the aniline ring exhibited selective inhibition against S. aureus. Amongst these compounds 6c was found to be the most potent against Bacillus subtilis and Candida albicans. Moreover, other compounds also found to be potential antibacterial agents in comparison to the standard drugs. Methods: On the basis of the above findings and in continuation of our search on 1,3,4-Oxadiazole derivatives with potential biological activity, we have synthesized new molecules based on 1,3,4-Oxadiazole ring system by incorporating methoxy pyridine moiety. Results: The synthetic route for the synthesis of title compounds were started with using commercially available acid. In the first place Esterification of starting meterial followed by treating with hydrazine hydrate afforded the compound, which upon reaction with benzoylchloride in the presence of POCl3 furnished oxadiazloe derivatives. Finally, the key intermediates 1,3,4-oxadiazole were coupled with various anilines using buchwald reaction gave the final compounds. The chemical structures of all the newly synthesized compounds were confirmed by their 1H NMR, 13C NMR, mass spectral data and elemental analysis. Further these compounds have been screened for their antibacterial, antifungal and nematicidal activities. Conclusion: Synthesis and screening of antibacterial and antifungal activities for a novel series of 1,3,4-Oxadiazole conjugates have been investigated. All the compounds have shown mild to potent inhibitory activity against B. subtilis and exhibited mild to moderate antibacterial activities against the other tested organisms. Compounds 6c and 6e were found to be the most active against most of the tested organisms. Some of the compounds have shown significant antibacterial activity in comparison to the controls.

Novel Bicyclic Pyridinones

Compounds and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula I as defined herein. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.