121433-95-2Relevant academic research and scientific papers
NONCATALEPTIC NEUROLEPTIC AGENTS: 2-(4-(2-(2-CHLORO-10,11-DIHYDRODIBENZOTHIEPIN-10-YLOXY)ETHYL)PIPERAZINE-1-YL)ETHANOL AND SOME RELATED COMPOUNDS
Jilek, Jiri,Valchar, Martin,Holubek, Jiri,Dlohozkova, Natasa,Pomykacek, Josef,et al.
, p. 2731 - 2741 (2007/10/02)
10-(2-Bromoethoxy)-2-chloro-10,11,dihydrodibenzothiepin (X), prepared by two methods, was subjected to substitution reactions with 2-(1-piperazinyl)ethanol, 3-(1-piperazinyl)propanol, 1-methylpiperazine, 3-(1-piperazinyl)propionamide, piperazine, and 1-(ethoxycarbonyl)piperazine and gave the title compounds II-VII.The alcohol II was esterified by treatment with acid chlorides to compounds VIII and IX.Compounds II, V, and VIII proved to be noncataleptic neuroleptic agents and II (clopithepin, VUFB-17 076) was selected for preclinical studies.
