1214332-39-4

Basic information

• Product Name: 2-(5-METHOXYPYRIDIN-2-YL)ACETIC ACID
• Synonyms: 2-(5-METHOXYPYRIDIN-2-YL)ACETIC ACID;5-Methoxy-2-pyridineacetic acid;(5-methoxypyridin-2-yl)acetic acid;2-Pyridineacetic acid, 5-methoxy-
• CAS NO: 1214332-39-4
• Molecular Formula: C₈H₉NO₃
• Molecular Weight: 167.16196
• EINECS: -0
• Mol File: 1214332-39-4.mol

Chemical Properties

• Boiling Point: 320.9±27.0 °C(Predicted)
• Appearance: /
• Density: 1.246±0.06 g/cm3(Predicted)
• Storage Temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
• PKA: 4.57±0.10(Predicted)
• CAS DataBase Reference: 2-(5-METHOXYPYRIDIN-2-YL)ACETIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(5-METHOXYPYRIDIN-2-YL)ACETIC ACID(1214332-39-4)
• EPA Substance Registry System: 2-(5-METHOXYPYRIDIN-2-YL)ACETIC ACID(1214332-39-4)

Safety Data

• Hazardous Substances Data: 1214332-39-4(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
2-(5-methoxypyridin-2-yl)acetic acid is used as a building block for the synthesis of various pharmaceuticals due to its unique structural features and reactivity. It contributes to the development of new drugs by providing a versatile chemical scaffold that can be modified to create a range of therapeutic agents.
Used in Agrochemical Industry:
In the agrochemical field, 2-(5-methoxypyridin-2-yl)acetic acid is utilized as a precursor in the synthesis of agrochemicals. Its chemical properties allow it to be incorporated into the development of pesticides, herbicides, and other agricultural chemicals, enhancing crop protection and yield.
Used in Organic Chemistry Research:
2-(5-methoxypyridin-2-yl)acetic acid is employed as a research compound in organic chemistry. Its reactivity and structural features make it a valuable tool for studying reaction mechanisms, exploring new synthetic routes, and understanding the properties of related compounds. This research can lead to the discovery of novel applications and advancements in the field of organic chemistry.

Upstream product

• 1334784-81-4 tert-butyl cyano(5-methoxypyridin-2-yl)acetate 
• 105170-27-2 2-bromo-5-methoxypyridine 

Relevant articles and documents

Glutaminase inhibitors as well as compositions and applications thereof

The invention provides a series of heterocyclic compounds expressed in a formula I. The compound comprises glutaminase inhibition activity, and can be used for treating diseases and symptoms related to dysfunction of glutaminase or raising activity of glutaminase.

Evaluation and synthesis of polar aryl- and heteroaryl spiroazetidine-piperidine acetamides as ghrelin inverse agonists

Several polar heteroaromatic acetic acids and their piperidine amides were synthesized and evaluated as ghrelin or type 1a growth hormone secretagogue receptor (GHS-R1a) inverse agonists. Efforts to improve pharmacokinetic and safety profile was achieved

Discovery of PF-5190457, a potent, selective, and orally bioavailable ghrelin receptor inverse agonist clinical candidate

The identification of potent, highly selective orally bioavailable ghrelin receptor inverse agonists from a spiro-azetidino-piperidine series is described. Examples from this series have promising in vivo pharmacokinetics and increase glucose-stimulated insulin secretion in human whole and dispersed islets. A physicochemistry-based strategy to increase lipophilic efficiency for ghrelin receptor potency and retain low clearance and satisfactory permeability while reducing off-target pharmacology led to the discovery of 16h. Compound 16h has a superior balance of ghrelin receptor pharmacology and off-target selectivity. On the basis of its promising pharmacological and safety profile, 16h was advanced to human clinical trials.

2,3-DIHYDRO-1H-INDEN-1-YL-2,7-DIAZASPIRO[3.5] NONANE DERIVATIVES

The present invention provides a compound of Formula (I) or a pharmaceutically salt thereof wherein R1, R2, Ra, L, Z, Z1 and Z2 are as defined herein, that act as Ghrelin antagonists or inverse agonists; pharmaceutical compositions thereof; and methods of treating diseases, disorders, or conditions mediated by the antagonism of the Ghrelin receptor.