1214332-67-8

Basic information

• Product Name: 3-Pyridinecarboxylic acid, 5-broMo-2-chloro-, ethyl ester
• Synonyms: 3-Pyridinecarboxylic acid, 5-broMo-2-chloro-, ethyl ester;ethyl 5-broMo-2-chloronicotinate;Ethyl 5-bromo-2-chloropyridine-3-carboxylate
• CAS NO: 1214332-67-8
• Molecular Formula: C8H7BrClNO2
• Molecular Weight: 264.50368
• Mol File: 1214332-67-8.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: 3-Pyridinecarboxylic acid, 5-broMo-2-chloro-, ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Pyridinecarboxylic acid, 5-broMo-2-chloro-, ethyl ester(1214332-67-8)
• EPA Substance Registry System: 3-Pyridinecarboxylic acid, 5-broMo-2-chloro-, ethyl ester(1214332-67-8)

Safety Data

• Hazardous Substances Data: 1214332-67-8(Hazardous Substances Data)

Usage

General Description

3-Pyridinecarboxylic acid, 5-brom0-2-chloro-, ethyl ester is a chemical compound that is classified as an ester. It has a molecular formula of C8H7BrClNO2 and a molecular weight of 258.506 g/mol. The compound is commonly used as an intermediate in the synthesis of pharmaceuticals and agricultural chemicals. It is also known for its potential uses in organic synthesis and chemical research. However, caution should be taken when handling this compound, as it may pose health and safety risks if not used properly.

Upstream product

• 64-17-5 ethanol 
• 29241-65-4 5-bromo-2-chloronicotinic acid 
• 279248-42-9 3-bromo-5-(ethoxycarbonyl)pyridine-1-oxide 
• 609-71-2 2-hydroxy-3-carboxypyridine 
• 104612-36-4 5-bromo-2-hydroxynicotinic acid 

Downstream Products

• 1239355-44-2 ethyl 5-bromo-2-(4-chlorophenoxy)nicotinate 
• 1256818-64-0 5-bromofuro[2,3-b]pyridin-3(2H)-one 
• 1310416-59-1 ethyl 5-bromo-2-ethoxynicotinate 
• 1239355-45-3 5-bromo-2-(4-chlorophenoxy)nicotinic acid 
• 1239354-70-1 5-bromo-2-[(4-chlorophenyl)oxy]-N-[(1R)-2-(4-methylpiperazin-1-yl)-2-oxo-1-{[(phenylmethyl)oxy]methyl}ethyl]pyridine-3-carboxamide 

Relevant articles and documents

Hinge Binder Scaffold Hopping Identifies Potent Calcium/Calmodulin-Dependent Protein Kinase Kinase 2 (CAMKK2) Inhibitor Chemotypes

CAMKK2 is a serine/threonine kinase and an activator of AMPK whose dysregulation is linked with multiple diseases. Unfortunately, STO-609, the tool inhibitor commonly used to probe CAMKK2 signaling, has limitations. To identify promising scaffolds as starting points for the development of high-quality CAMKK2 chemical probes, we utilized a hinge-binding scaffold hopping strategy to design new CAMKK2 inhibitors. Starting from the potent but promiscuous disubstituted 7-azaindole GSK650934, a total of 32 compounds, composed of single-ring, 5,6-, and 6,6-fused heteroaromatic cores, were synthesized. The compound set was specifically designed to probe interactions with the kinase hinge-binding residues. Compared to GSK650394 and STO-609, 13 compounds displayed similar or better CAMKK2 inhibitory potency in vitro, while compounds 13g and 45 had improved selectivity for CAMKK2 across the kinome. Our systematic survey of hinge-binding chemotypes identified several potent and selective inhibitors of CAMKK2 to serve as starting points for medicinal chemistry programs.

TAM family kinase and/or CSF1R kinase inhibitor and application thereof

The invention provides a novel inhibitor compound shown in a general formula (I). The compound has good kinase inhibition activity and can be used for preventing and/or treating diseases mediated by abnormal expression of TAM family kinase and/or a ligand thereof. The compound can target CSF1R kinase and can be used for preventing and/or treating diseases mediated by abnormal expression of a TAM family kinase receptor and/or a CSF1R kinase receptor and/or ligands thereof.

Highly Regioselective Halogenation of Pyridine N -Oxide: Practical Access to 2-Halo-Substituted Pyridines

A highly efficient and regioselective halogenation reaction of unsymmetrical pyridine N-oxide under mild conditions is described. The methodology provides a practical access to various 2-halo-substituted pyridines, which are pharmaceutically important intermediates.