1214740-45-0Relevant academic research and scientific papers
Novel quinolines and pyrimido[4,5-b]quinolines bearing biologically active sulfonamide moiety as a new class of antitumor agents
Alqasoumi, Saleh I.,Al-Taweel, Areej M.,Alafeefy, Ahmed M.,Noaman, Eman,Ghorab, Mostafa M.
, p. 738 - 744 (2010)
Some novel quinolines and pyrimido[4,5-b]quinolines have been synthesized. The structures of which were confirmed by elemental analyses and spectral data. All the target compounds were subjected to in-vitro antitumor activity against Ehrlich Ascites Carcinoma (EAC) cells. Compounds 24, 19 and 12 showed higher activity with IC50 values (5.5, 6.9, 7 μg/ml) when compared with Doxorubicin as a reference drug (IC50 value 38 μg/ml).
